Journal article
New types of toxin A-negative, toxin B-positive strains among clinical isolates of Clostridium difficile in Australia
Journal of Medical Microbiology, Vol.60(8), pp.1108-1111
2011
Abstract
A total of 817 human clinical isolates of Clostridium difficile from all Australian states were screened for A-B+ strains by toxin gene PCR assays. Nine (1.1%) strains were confirmed to be A-B+ by enzyme immunoassay for toxin production. Of these, six (66.7%) were binary toxinpositive by PCR. Using PCR ribotyping and toxinotyping, the A-B+ strains could be grouped into seven ribotypes and three toxinotypes. Only one of the ribotypes had been reported previously (017). The prevalence of ribotype 017 was low in this study with only two strains detected. Two new A-B+ toxinotypes were also defined (XXX, XXXI). Toxinotype XXX had a toxin B gene similar to that of toxinotype IV (A+B+) but with a novel cytopathic region. Toxinotype XXXI was similar to other A-B+ types (X, XVII), but had a larger deletion to the toxin A gene than in either of those types. The types of A-B+ strains identified in this study differed markedly from those described in other regions.
Details
- Title
- New types of toxin A-negative, toxin B-positive strains among clinical isolates of Clostridium difficile in Australia
- Authors/Creators
- B. Elliott (Author/Creator)M.M. Squire (Author/Creator)S. Thean (Author/Creator)B.J. Chang (Author/Creator)J.S. Brazier (Author/Creator)M. Rupnik (Author/Creator)T.V. Riley (Author/Creator)
- Publication Details
- Journal of Medical Microbiology, Vol.60(8), pp.1108-1111
- Publisher
- Society for General Microbiology
- Identifiers
- 991005541480407891
- Copyright
- © 2011 SGM.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.120 Inflammatory Bowel Diseases & Infections
- 1.120.1133 Clostridium Infections
- Web Of Science research areas
- Microbiology
- ESI research areas
- Microbiology