Nitric oxide mediates caeruleininduced suppression of locomotor activity

V. Volke; A. Soosaar; S. Kõks; M. Bourin; P.T. Männistö; E. Vasar

doi:10.1016/S0143-4179(96)90020-7

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Nitric oxide mediates caeruleininduced suppression of locomotor activity

Journal article

Peer reviewed

Nitric oxide mediates caeruleininduced suppression of locomotor activity

V. Volke, A. Soosaar, S. Kõks, M. Bourin, P.T. Männistö and E. Vasar

Neuropeptides, Vol.30(4), pp.323-326

1996

DOI: https://doi.org/10.1016/S0143-4179(96)90020-7

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Abstract

Caerulein, a non-selective agonist of cholecystokinin (CCK) receptors, is shown to suppress locomotor activity in rodents via stimulation of CCKA receptors. In the present study we examined the possible involvement of nitric oxide (NO) in caerulein-induced hypolocomotion in rats. Caerulein (10 μg/kg) markedly decreased the horizontal and vertical components of locomotor activity in rats measured in dark motility boxes. Pretreatment with a nitric oxide synthase inhibitor NG-nitro-l-arginine methyl ester (l-NAME), at 5 mg/kg i.p., abolished the inhibiting action of caerulein on the horizontal activity, but did not affect the reduced frequency of rearing. The other doses of l-NAME (1, 10 and 20 mg/kg) were ineffective against caerulein. As L-NAME at this dose range does not stimulate locomotor activity, it is likely that NO is involved in the motor suppressant effect of systemically administered caerulein.

Details

Title: Nitric oxide mediates caeruleininduced suppression of locomotor activity
Authors/Creators: V. Volke (Author/Creator)
A. Soosaar (Author/Creator)
S. Kõks (Author/Creator)
M. Bourin (Author/Creator)
P.T. Männistö (Author/Creator)
E. Vasar (Author/Creator)
Publication Details: Neuropeptides, Vol.30(4), pp.323-326
Publisher: Elsevier
Identifiers: 991005541430007891
Copyright: © 1996 Elsevier Ltd.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.195 Neuroendocrine & Intestinal Disorders; 1.195.1096 Gastrin/CCK Functions
Web Of Science research areas: Endocrinology & Metabolism; Neurosciences
ESI research areas: Neuroscience & Behavior