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CC BY V4.0, Open Access
Journal article
No associations between C-reactive protein and spinal pain trajectories in children and adolescents (CHAMPS study-DK)
Scientific reports, Vol.12(1), 20001
2022
PMID: 36411323
Abstract
Preliminary evidence points to a link between C-reactive protein (CRP) and spinal pain in adults. However, there is a paucity of research in younger populations. Therefore, we aimed to determine associations between CRP and spinal pain in childhood and adolescence. We identified trajectories of spinal pain from childhood to adolescence and investigated the associations between CRP and trajectory subgroups. Six- to 11-year-old children from 13 primary schools, were followed from October 2008 and until 2014. High-sensitivity CRP collected at baseline (2008) was measured using serum samples. The outcome was the number of weeks with non-traumatic spinal pain between November 2008 and June 2014. We constructed a trajectory model to identify different spinal pain trajectory subgroups. The associations between CRP and spinal pain trajectory subgroups were modelled using mixed-effects multinominal logistic regression. Data from 1556 participants (52% female), with a mean age of 8.4 years at baseline, identified five spinal pain trajectory subgroups: "no pain" (55.3%), "rare" (23.7%), "rare, increasing" (13.6%), "moderate, increasing" (6.1%), and "early onset, decreasing" (1.3%). There were no differences in baseline high-sensitivity CRP levels between spinal pain trajectory subgroups. Thus, the heterogeneous courses of spinal pain experienced were not defined by differences in CRP at baseline.
Details
- Title
- No associations between C-reactive protein and spinal pain trajectories in children and adolescents (CHAMPS study-DK)
- Authors/Creators
- Amber M. Beynon - Macquarie UniversityNiels Wedderkopp - University of Southern DenmarkBruce F. Walker - Murdoch Univ, Coll Sci Hlth Engn & Educ, Perth, WA, AustraliaCharlotte Leboeuf-Yde - Univ Southern Denmark, Dept Reg Hlth Res, Odense, DenmarkJan Hartvigsen - University of Southern DenmarkBobby Jones - University of PittsburghIan Shrier - McGill University Health CentreChinchin Wang - McGill UniversityJeffrey J. Hebert - Murdoch Univ, Coll Sci Hlth Engn & Educ, Perth, WA, Australia
- Publication Details
- Scientific reports, Vol.12(1), 20001
- Publisher
- NATURE PORTFOLIO
- Number of pages
- 8
- Grant note
- Ostifternes Foundation Egmont Foundation IMK foundation Western Australia Chiropractic Australia Research Foundation Region of Southern Denmark Murdoch University TRYG Foundation University College Lillebaelt Danish Rheumatism Association Brd. Hartmann's Foundation TEAM Denmark Nordic Institute of Chiropractic and Clinical Biomechanics University of Southern Denmark A.J. Andersen Foundation Nordea Foundation Danish Chiropractor Foundation
- Identifiers
- 991005585967807891
- Copyright
- © 2022 The Author(s)
- Murdoch Affiliation
- College of Science, Technology, Engineering and Mathematics
- Language
- English
- Resource Type
- Journal article
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- 1 Clinical & Life Sciences
- 1.129 Back pain
- 1.129.98 Low Back Pain
- Web Of Science research areas
- Orthopedics
- ESI research areas
- Clinical Medicine