Journal article
No difference observed in short-interval intracortical inhibition in older burn-injury survivors compared to non-injured older adults: A pilot study
Burns, Vol.45(5), pp.1131-1138
2019
Abstract
Objective
The study aimed to investigate short-interval intracortical inhibition (SICI) in burns survivors and non-injured controls, and establish whether paired-pulse transcranial magnetic stimulation (TMS) is a sensitive tool to investigate SICI after burn-injury.
Methods
Burn survivors underwent experimental assessments at 6- and 12-weeks after injury, and control participants underwent two equivalent sessions 6 weeks apart. Single-pulse transcranial magnetic stimulation (TMS) was used to record motor-evoked potentials (MEPs) from a hand muscle and paired-pulse TMS was used to measure SICI. Functional measures were obtained for comparison at 12-weeks after injury.
Results
There was no significant difference in SICI between burns survivors and non-injured controls at either 6- or 12-weeks after burn injury. There was no evidence of correlations between SICI and functional outcome measures in burns survivors.
Conclusions
These results show that paired-pulse TMS is a useful method for investigating cortical inhibition following burn injury, and that SICI circuits in the primary motor cortex are not affected by minor burn injury. This study presents details for definitive future studies of primary motor cortex function after minor burn injury.
Details
- Title
- No difference observed in short-interval intracortical inhibition in older burn-injury survivors compared to non-injured older adults: A pilot study
- Authors/Creators
- C.J. Whife (Author/Creator) - The University of Western AustraliaA-M Vallence (Author/Creator) - Murdoch UniversityD.W. Edgar (Author/Creator) - The University of Notre Dame AustraliaF.M. Wood (Author/Creator) - The University of Western Australia
- Publication Details
- Burns, Vol.45(5), pp.1131-1138
- Publisher
- Elsevier
- Identifiers
- 991005540312707891
- Copyright
- © 2019 Elsevier Ltd and ISBI
- Murdoch Affiliation
- School of Psychology and Exercise Science
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.82 Gait & Posture
- 1.82.811 Transcranial Magnetic Stimulation
- Web Of Science research areas
- Critical Care Medicine
- Dermatology
- Surgery
- ESI research areas
- Clinical Medicine