Journal article
No evidence of major transcriptional changes in the brain of mice exposed to 1800 MHz GSM signal
Bioelectromagnetics, Vol.29(4), pp.312-323
2008
Abstract
To analyze possible effects of microwaves on gene expression, mice were exposed to global system for mobile communication (GSM) 1800 MHz signal for 1 h at a whole body SAR of 1.1 W/kg. Gene expression was studied in the whole brain, where the average SAR was 0.2 W/kg, by expression microarrays containing over 22,600 probe sets. Comparison of data from sham and exposed animals showed no significant difference in gene expression modulation. However, when less stringent constraints were adopted to analyze microarray results, 75 genes were found to be modulated following exposure. Forty-two probes showed fold changes ranging from 1.5 to 2.8, whereas 33 were down-regulated from 0.67- to 0.29-fold changes, but these differences in gene expression were not confirmed by real-time PCR. Under these specific limited conditions, no consistent indication of gene expression modulation in whole mouse brain was found associated to GSM 1800 MHz exposure.
Details
- Title
- No evidence of major transcriptional changes in the brain of mice exposed to 1800 MHz GSM signal
- Authors/Creators
- A. Paparini (Author/Creator) - Department of Health Sciences, Public Health Unit, University Institute of Movement Sciences (IUSM), Rome, ItalyP. Rossi (Author/Creator) - Institute of Occupational SafetyG. Gianfranceschi (Author/Creator) - Department of Health Sciences, Public Health Unit, University Institute of Movement Sciences (IUSM), Rome, ItalyV. Brugaletta (Author/Creator) - Institute of Occupational SafetyR. Falsaperla (Author/Creator) - Institute of Occupational SafetyP. De Luca (Author/Creator) - CoreV. Romano Spica (Author/Creator)
- Publication Details
- Bioelectromagnetics, Vol.29(4), pp.312-323
- Publisher
- Wiley-Liss Inc.
- Identifiers
- 991005543031807891
- Copyright
- © 2008 Wiley-Liss, Inc.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- 4 Electrical Engineering, Electronics & Computer Science
- 4.289 Biophotonics & Electromagnetic Field Safety
- 4.289.731 EMF Bioeffects
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