Nodal changes during the early stages of Wallerian degeneration of central nerve fibres

F.L. Mastaglia; W.I. McDonald; K. Yogendran

doi:10.1016/0022-510X(76)90132-5

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Nodal changes during the early stages of Wallerian degeneration of central nerve fibres

Journal article

Peer reviewed

Nodal changes during the early stages of Wallerian degeneration of central nerve fibres

F.L. Mastaglia, W.I. McDonald and K. Yogendran

Journal of the Neurological Sciences, Vol.30(2-3), pp.259-267

1976

DOI: https://doi.org/10.1016/0022-510X(76)90132-5

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Abstract

The nodal changes in central nerve fibres undergoing Wallerian degeneration have been studied during the first 48 hr after section of the dorsal columns of the rat by single fibre teasing and by conventional light and electron microscopic techniques. The earliest changes found at 24 hr consisted of an accumulation of mitochondria, other organelles and lamellar bodies in the nodal axoplasm. Attenuation of the myelin sheath on one side of the node due to detachment of terminal myelin loops and slipping of the outer myelin lamellae was found in some fibres, and varying degrees of nodal widening in others at 24 hr. The functional significance of these early changes in the nodal region is uncertain.

Details

Title: Nodal changes during the early stages of Wallerian degeneration of central nerve fibres
Authors/Creators: F.L. Mastaglia (Author/Creator) - UCL Institute of Neurology
W.I. McDonald (Author/Creator) - UCL Institute of Neurology
K. Yogendran (Author/Creator) - UCL Institute of Neurology
Publication Details: Journal of the Neurological Sciences, Vol.30(2-3), pp.259-267
Publisher: Elsevier BV
Identifiers: 991005540019907891
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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