Non-archetypal Type II-like and atypical strains of Toxoplasma gondii infecting marsupials of Australia

N. Parameswaran; R.C.A. Thompson; N. Sundar; S. Pan; M. Johnson; N.C. Smith; M.E. Grigg

doi:10.1016/j.ijpara.2010.02.008

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Non-archetypal Type II-like and atypical strains of Toxoplasma gondii infecting marsupials of Australia

Journal article

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Peer reviewed

Non-archetypal Type II-like and atypical strains of Toxoplasma gondii infecting marsupials of Australia

N. Parameswaran, R.C.A. Thompson, N. Sundar, S. Pan, M. Johnson, N.C. Smith and M.E. Grigg

International Journal for Parasitology, Vol.40(6), pp.635-640

2010

DOI: https://doi.org/10.1016/j.ijpara.2010.02.008

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Abstract

Australia is geographically isolated and possesses a remarkable diversity of wildlife species. Marsupials are highly susceptible to infection with the cosmopolitan parasite Toxoplasma gondii. Of 46 marsupials screened for T. gondii by multilocus PCR-DNA sequencing at polymorphic genes (B1, SAG3, GRA6, GRA7), 12 were PCR-positive; the majority (67%; 9/12) were infected by non-archetypal Type II-like or atypical strains. Six novel alleles were detected at B1, indicating greater diversity of genotypes than previously envisaged. Two isolates lethal to marsupials, were avirulent to mice. The data support the conclusion that Australia's isolation may have favoured the persistence of non-archetypal ancestral genotypes.

Details

Title: Non-archetypal Type II-like and atypical strains of Toxoplasma gondii infecting marsupials of Australia
Authors/Creators: N. Parameswaran (Author/Creator)
R.C.A. Thompson (Author/Creator)
N. Sundar (Author/Creator)
S. Pan (Author/Creator)
M. Johnson (Author/Creator)
N.C. Smith (Author/Creator)
M.E. Grigg (Author/Creator)
Publication Details: International Journal for Parasitology, Vol.40(6), pp.635-640
Publisher: Elsevier BV
Identifiers: 991005544810907891
Copyright: © 2010 Elsevier B.V.
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.217 Parasitology - Malaria, Toxoplasmosis & Coccidiosis; 1.217.1038 Toxoplasma Gondii
Web Of Science research areas: Parasitology
ESI research areas: Microbiology