Non-invasive measurement and imaging of tissue iron oxide nanoparticle concentrations in vivo using proton relaxometry

T.G. St Pierre; P.R. Clark; W. Chua-anusorn; A. Fleming; H. Pardoe; G.P. Jeffrey; J.K. Olynyk; P. Pootrakul; S. Jones; P. Moroz

doi:10.1088/1742-6596/17/1/018

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Non-invasive measurement and imaging of tissue iron oxide nanoparticle concentrations in vivo using proton relaxometry

Journal article

Open access

Peer reviewed

Non-invasive measurement and imaging of tissue iron oxide nanoparticle concentrations in vivo using proton relaxometry

T.G. St Pierre, P.R. Clark, W. Chua-anusorn, A. Fleming, H. Pardoe, G.P. Jeffrey, J.K. Olynyk, P. Pootrakul, S. Jones and P. Moroz

Journal of Physics: Conference Series, Vol.17, pp.122-126

2005

DOI: https://doi.org/10.1088/1742-6596/17/1/018

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Abstract

Magnetic nanoparticles and microparticles can be found in biological tissues for a variety of reasons including pathological deposition of biogenic particles, administration of synthetic particles for scientific or clinical reasons, and the inclusion of biogenic magnetic particles for the sensing of the geomagnetic field. In applied magnetic fields, the magnetisation of tissue protons can be manipulated with radiofrequency radiation such that the macroscopic magnetisation of the protons precesses freely in the plane perpendicular to the applied static field. The presence of magnetic particles within tissue enhances the rate of dephasing of proton precession with higher concentrations of particles resulting in higher dephasing rates. Magnetic resonance imaging instruments can be used to measure and image the rate of decay of spin echo recoverable proton transverse magnetisation (R2) within tissues enabling the measurement and imaging of magnetic particle concentrations with the aid of suitable calibration curves. Applications include the non-invasive measurement of liver iron concentrations in iron-overload disorders and measurement and imaging of magnetic particle concentrations used in magnetic hyperthermia therapy. Future applications may include the tracking of magnetically labelled drugs or biomolecules and the measurement of fibrotic liver damage.

Details

Title: Non-invasive measurement and imaging of tissue iron oxide nanoparticle concentrations in vivo using proton relaxometry
Authors/Creators: T.G. St Pierre (Author/Creator)
P.R. Clark (Author/Creator) - The University of Western Australia
W. Chua-anusorn (Author/Creator) - The University of Western Australia
A. Fleming (Author/Creator) - The University of Western Australia
H. Pardoe (Author/Creator) - The University of Western Australia
G.P. Jeffrey (Author/Creator) - The University of Western Australia
J.K. Olynyk (Author/Creator) - The University of Western Australia
P. Pootrakul (Author/Creator) - Mahidol University
S. Jones (Author/Creator) - Rex Medical (United States)
P. Moroz (Author/Creator) - The University of Western Australia
Publication Details: Journal of Physics: Conference Series, Vol.17, pp.122-126
Publisher: Institute of Physics Publishing
Identifiers: 991005541721707891
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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