Journal article
Non-lamellar lipid assembly at interfaces: controlling layer structure by responsive nanogel particles
Interface Focus, Vol.7(4)
2017
Abstract
Biological membranes do not only occur as planar bilayer structures, but depending on the lipid composition, can also curve into intriguing threedimensional structures. In order to fully understand the biological implications as well as to reveal the full potential for applications, e.g. for drug delivery and other biomedical devices, of such structures, well-defined model systems are required. Here, we discuss the formation of lipid nonlamellar liquid crystalline (LC) surface layers spin-coated from the constituting lipids followed by hydration of the lipid layer. We demonstrate that hybrid lipid polymer films can be formed with different properties compared with the neat lipid LC layers. The nanostructure and morphologies of the lipid films formed reflect those in the bulk. Most notably, mixed lipid layers, which are composed of glycerol monooleate and diglycerol monooleate with poly(N-isopropylacrylamide) nanogels, can form films of reverse cubic phases that are capable of responding to temperature stimulus. Owing to the presence of the nanogel particles, changing the temperature not only regulates the hydration of the cubic phase lipid films, but also the lateral organization of the lipid domains within the lipid self-assembled film. This opens up the possibility for new nanostructured materials based on lipid-polymer responsive layers.
Details
- Title
- Non-lamellar lipid assembly at interfaces: controlling layer structure by responsive nanogel particles
- Authors/Creators
- A.P. Dabkowska (Author/Creator) - Lund UniversityM. Valldeperas (Author/Creator) - Lund UniversityC. Hirst (Author/Creator) - Lund UniversityC. Montis (Author/Creator)G.K. Pálsson (Author/Creator) - Uppsala UniversityM. Wang (Author/Creator) - Lund UniversityS. Nöjd (Author/Creator) - Lund UniversityL. Gentile (Author/Creator) - Lund UniversityJ. Barauskas (Author/Creator) - Malmö UniversityN.-J. Steinke (Author/Creator) - Science and Technology Facilities CouncilG.E. Schröder-Turk (Author/Creator)S. George (Author/Creator) - Uppsala UniversityM.W.A. Skoda (Author/Creator) - Science and Technology Facilities CouncilT. Nylander (Author/Creator) - Lund University
- Publication Details
- Interface Focus, Vol.7(4)
- Publisher
- Royal Society Publishing
- Identifiers
- 991005543336707891
- Copyright
- © 2017 The Author(s) Published by the Royal Society. All rights reserved.
- Murdoch Affiliation
- School of Engineering and Information Technology
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 2 Chemistry
- 2.190 Surfactants, Lipid Bilayers & Antimicrobial Peptides
- 2.190.215 Critical Micelle Concentration
- Web Of Science research areas
- Biology
- ESI research areas
- Biology & Biochemistry