Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance

T.G. St Pierre; P.R. Clark; W. Chua-anusorn; A.J. Fleming; G.P. Jeffrey; J.K. Olynyk; P. Pootrakul; E. Robins; R. Lindeman

doi:10.1182/blood-2004-01-0177

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Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance

Journal article

Peer reviewed

Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance

T.G. St Pierre, P.R. Clark, W. Chua-anusorn, A.J. Fleming, G.P. Jeffrey, J.K. Olynyk, P. Pootrakul, E. Robins and R. Lindeman

Blood, Vol.105(2), pp.855-861

2005

DOI: https://doi.org/10.1182/blood-2004-01-0177

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Abstract

Measurement of liver iron concentration (LIC) is necessary for a range of iron-loading disorders such as hereditary hemochromatosis, thalassemia, sickle cell disease, aplastic anemia, and myelodysplasia. Currently, chemical analysis of needle biopsy specimens is the most common accepted method of measurement. This study presents a readily available noninvasive method of measuring and imaging LICs in vivo using clinical 1.5-T magnetic resonance imaging units. Mean liver proton transverse relaxation rates (R2) were measured for 105 humans. A value for the LIC for each subject was obtained by chemical assay of a needle biopsy specimen. High degrees of sensitivity and specificity of R2 to biopsy LICs were found at the clinically significant LIC thresholds of 1.8, 3.2, 7.0, and 15.0 mg Fe/g dry tissue. A calibration curve relating liver R2 to LIC has been deduced from the data covering the range of LICs from 0.3 to 42.7 mg Fe/g dry tissue. Proton transverse relaxation rates in aqueous paramagnetic solutions were also measured on each magnetic resonance imaging unit to ensure instrument-independent results. Measurements of proton transverse relaxivity of aqueous MnCl2 phantoms on 13 different magnetic resonance imaging units using the method yielded a coefficient of variation of 2.1%.

Details

Title: Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance
Authors/Creators: T.G. St Pierre (Author/Creator)
P.R. Clark (Author/Creator) - The University of Western Australia
W. Chua-anusorn (Author/Creator) - The University of Western Australia
A.J. Fleming (Author/Creator) - The University of Western Australia
G.P. Jeffrey (Author/Creator) - The University of Western Australia
J.K. Olynyk (Author/Creator) - The University of Western Australia
P. Pootrakul (Author/Creator) - The University of Western Australia
E. Robins (Author/Creator) - The University of Western Australia
R. Lindeman (Author/Creator) - The University of Western Australia
Publication Details: Blood, Vol.105(2), pp.855-861
Publisher: American Society of Hematology
Identifiers: 991005540153207891
Copyright: © 2005 The American Society of Hematology
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.184 Physiology & Metals; 1.184.573 Iron Metabolism
Web Of Science research areas: Hematology
ESI research areas: Clinical Medicine