Journal article
Normobaric hyperoxic stress in budgerigars: enzymic antioxidants and lipid peroxidation
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, Vol.128(2), pp.173-180
2001
Abstract
The effects of acute (3 h), repeated acute (3 exposures each of 3 h) and chronic (72 h) normobaric hyperoxic exposure in budgerigars (Melopsittacus undulatus) were evaluated by monitoring the effects on pulmonary enzymic antioxidants, and indicators of lipid peroxidation. All durations of oxygen exposure resulted in significant respiratory alkalosis and elevated pulmonary and blood glutathione peroxidase concentrations. The concentrations of other pulmonary enzymic antioxidants including glutathione reductase and superoxide dismutase were not significantly altered by oxygen exposure. Pulmonary concentrations of the lipid peroxidation markers malonaldehyde and 4-hydroxyalkenal were not significantly elevated following oxygen exposure. Plasma concentrations of 8-epi isoprostane F2α were significantly elevated following both acute and repeated acute exposure. The results indicate that in budgerigars, both acute and chronic oxygen exposure can result in significant alteration in respiratory function and increased production of reactive oxygen species.
Details
- Title
- Normobaric hyperoxic stress in budgerigars: enzymic antioxidants and lipid peroxidation
- Authors/Creators
- S. Jaensch (Author/Creator) - Murdoch UniversityL. Cullen (Author/Creator) - Murdoch UniversityS.R. Raidal (Author/Creator) - Murdoch University
- Publication Details
- Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, Vol.128(2), pp.173-180
- Publisher
- Elsevier Inc.
- Identifiers
- 991005544804607891
- Copyright
- © 2001 Elsevier Science Inc.
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.154 Assisted Ventilation
- 1.154.1057 Pulmonary Surfactant
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Endocrinology & Metabolism
- Toxicology
- Zoology
- ESI research areas
- Biology & Biochemistry