Journal article
Normobaric hyperoxic stress in budgerigars: non-enzymic antioxidants
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, Vol.128(2), pp.181-187
2001
Abstract
The effects of oxygen exposure on pulmonary and blood non-enzymic antioxidant concentrations was evaluated in budgerigars (Melopsittacus undulatus). Budgerigars were exposed to acute (3 h), repeated acute (3 exposures each of 3 h) or chronic (72 h) normobaric hyperoxic environments and the pulmonary and plasma concentrations of selected non-enzymic antioxidants, namely glutathione, uric acid, α- and γ-tocopherol and carotenoids were assayed. With increasing duration of oxygen exposure, the ratio of oxidised to reduced glutathione was significantly increased, while the concentrations of uric acid, α- and γ-tocopherol and carotenoids were significantly reduced, especially following chronic oxygen exposure. Following acute and repeated acute exposure, alteration in glutathione concentrations and reduction in α-tocopherol concentrations indicated oxygen stress. Following chronic exposure, depletion of non-enzymic antioxidants indicated exhaustion of these protective mechanisms and progression from oxygen stress to oxygen toxicity.
Details
- Title
- Normobaric hyperoxic stress in budgerigars: non-enzymic antioxidants
- Authors/Creators
- S. Jaensch (Author/Creator) - Murdoch UniversityL. Cullen (Author/Creator) - Murdoch UniversityL. Morton (Author/Creator) - The University of Western AustraliaS.R. Raidal (Author/Creator) - Murdoch University
- Publication Details
- Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, Vol.128(2), pp.181-187
- Publisher
- Elsevier Inc.
- Identifiers
- 991005544792007891
- Copyright
- © 2001 Elsevier Science Inc.
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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