Novel Hendra Virus Variant Detected by Sentinel Surveillance of Horses in Australia

E.J. Annand; B.A. Horsburgh; K. Xu; P.A. Reid; B. Poole; M.C. de Kantzow; N. Brown; A. Tweedie; M. Michie; J.D. Grewar; A.E. Jackson; N.B. Singanallur; K.M. Plain; K. Kim; M. Tachedjian; B. van der Heide; S. Crameri; D.T. Williams; C. Secombe; E.D. Laing; S. Sterling; L. Yan; L. Jackson; C. Jones; R.K. Plowright; A.J. Peel; A.C. Breed; I. Diallo; N.K. Dhand; P.N. Britton; C.C. Broder; I. Smith; J-S Eden

doi:10.3201/eid2803.211245

Back

Novel Hendra Virus Variant Detected by Sentinel Surveillance of Horses in Australia

Journal article

Peer reviewed

Novel Hendra Virus Variant Detected by Sentinel Surveillance of Horses in Australia

E.J. Annand, B.A. Horsburgh, K. Xu, P.A. Reid, B. Poole, M.C. de Kantzow, N. Brown, A. Tweedie, M. Michie, J.D. Grewar, …

Emerging Infectious Diseases, Vol.28(3), pp.693-704

2022

DOI: https://doi.org/10.3201/eid2803.211245

Files and links (1)

url

Link to Published Version *Subscription may be requiredView

Abstract

We identified and isolated a novel Hendra virus (HeV) variant not detected by routine testing from a horse in Queensland, Australia, that died from acute illness with signs consistent with HeV infection. Using whole-genome sequencing and phylogenetic analysis, we determined the variant had ≈83% nt identity with prototypic HeV. In silico and in vitro comparisons of the receptor-binding protein with prototypic HeV support that the human monoclonal antibody m102.4 used for postexposure prophylaxis and current equine vaccine will be effective against this variant. An updated quantitative PCR developed for routine surveillance resulted in subsequent case detection. Genetic sequence consistency with virus detected in grey-headed flying foxes suggests the variant circulates at least among this species. Studies are needed to determine infection kinetics, pathogenicity, reservoir-species associations, viral-host coevolution, and spillover dynamics for this virus. Surveillance and biosecurity practices should be updated to acknowledge HeV spillover risk across all regions frequented by flying foxes.

Details

Title: Novel Hendra Virus Variant Detected by Sentinel Surveillance of Horses in Australia
Authors/Creators: E.J. Annand (Author/Creator)
B.A. Horsburgh (Author/Creator)
K. Xu (Author/Creator)
P.A. Reid (Author/Creator)
B. Poole (Author/Creator)
M.C. de Kantzow (Author/Creator)
N. Brown (Author/Creator)
A. Tweedie (Author/Creator)
M. Michie (Author/Creator)
J.D. Grewar (Author/Creator)
A.E. Jackson (Author/Creator)
N.B. Singanallur (Author/Creator)
K.M. Plain (Author/Creator)
K. Kim (Author/Creator)
M. Tachedjian (Author/Creator)
B. van der Heide (Author/Creator)
S. Crameri (Author/Creator)
D.T. Williams (Author/Creator)
C. Secombe (Author/Creator)
E.D. Laing (Author/Creator)
S. Sterling (Author/Creator)
L. Yan (Author/Creator)
L. Jackson (Author/Creator)
C. Jones (Author/Creator)
R.K. Plowright (Author/Creator)
A.J. Peel (Author/Creator)
A.C. Breed (Author/Creator)
I. Diallo (Author/Creator)
N.K. Dhand (Author/Creator)
P.N. Britton (Author/Creator)
C.C. Broder (Author/Creator)
I. Smith (Author/Creator)
J-S Eden (Author/Creator)
Publication Details: Emerging Infectious Diseases, Vol.28(3), pp.693-704
Publisher: National Center for Infectious Diseases
Identifiers: 991005544071507891
Murdoch Affiliation: School of Veterinary Medicine
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

75 Record Views

38 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.104 Virology - General; 1.104.568 Viral Disease Dynamics
Web Of Science research areas: Immunology; Infectious Diseases
ESI research areas: Immunology