Journal article
Novel Hendra Virus Variant Detected by Sentinel Surveillance of Horses in Australia
Emerging Infectious Diseases, Vol.28(3), pp.693-704
2022
Abstract
We identified and isolated a novel Hendra virus (HeV) variant not detected by routine testing from a horse in Queensland, Australia, that died from acute illness with signs consistent with HeV infection. Using whole-genome sequencing and phylogenetic analysis, we determined the variant had ≈83% nt identity with prototypic HeV. In silico and in vitro comparisons of the receptor-binding protein with prototypic HeV support that the human monoclonal antibody m102.4 used for postexposure prophylaxis and current equine vaccine will be effective against this variant. An updated quantitative PCR developed for routine surveillance resulted in subsequent case detection. Genetic sequence consistency with virus detected in grey-headed flying foxes suggests the variant circulates at least among this species. Studies are needed to determine infection kinetics, pathogenicity, reservoir-species associations, viral-host coevolution, and spillover dynamics for this virus. Surveillance and biosecurity practices should be updated to acknowledge HeV spillover risk across all regions frequented by flying foxes.
Details
- Title
- Novel Hendra Virus Variant Detected by Sentinel Surveillance of Horses in Australia
- Authors/Creators
- E.J. Annand (Author/Creator)B.A. Horsburgh (Author/Creator)K. Xu (Author/Creator)P.A. Reid (Author/Creator)B. Poole (Author/Creator)M.C. de Kantzow (Author/Creator)N. Brown (Author/Creator)A. Tweedie (Author/Creator)M. Michie (Author/Creator)J.D. Grewar (Author/Creator)A.E. Jackson (Author/Creator)N.B. Singanallur (Author/Creator)K.M. Plain (Author/Creator)K. Kim (Author/Creator)M. Tachedjian (Author/Creator)B. van der Heide (Author/Creator)S. Crameri (Author/Creator)D.T. Williams (Author/Creator)C. Secombe (Author/Creator)E.D. Laing (Author/Creator)S. Sterling (Author/Creator)L. Yan (Author/Creator)L. Jackson (Author/Creator)C. Jones (Author/Creator)R.K. Plowright (Author/Creator)A.J. Peel (Author/Creator)A.C. Breed (Author/Creator)I. Diallo (Author/Creator)N.K. Dhand (Author/Creator)P.N. Britton (Author/Creator)C.C. Broder (Author/Creator)I. Smith (Author/Creator)J-S Eden (Author/Creator)
- Publication Details
- Emerging Infectious Diseases, Vol.28(3), pp.693-704
- Publisher
- National Center for Infectious Diseases
- Identifiers
- 991005544071507891
- Murdoch Affiliation
- School of Veterinary Medicine
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.104 Virology - General
- 1.104.568 Viral Disease Dynamics
- Web Of Science research areas
- Immunology
- Infectious Diseases
- ESI research areas
- Immunology