Journal article
Novel, cross-restricted, conserved, and immunodominant Cytotoxic T Lymphocyte epitopes in slow progressors in HIV Type 1 infection
AIDS Research and Human Retroviruses, Vol.12(18), pp.1691-1698
1996
Abstract
HIV-specific cytotoxic T lymphocytes (CTLs) play an important role in the immune response to HIV infection. Long-term nonprogressors (LTNPs) or slow progressors (SPs) in HIV infection may make qualitatively different CTL responses compared to those generated by seropositive individuals who progress to disease at a faster rate. The class I molecule HLA-B*57 has been identified as one restriction element overrepresented in SP groups studied, and, together with the closely related molecule HLA-B*58, occurs commonly in ethnic groups where HTV is most prevalent. In this study, we have identified five new HLA-B*57-restricted CTL epitopes recognized by SP donors, one of which is also HLA-B*5801 restricted. These HLA-B*57-restricted responses represent the dominant HIV-specific CTL response in each of the SP donors tested. These and other such epitopes may be an important component in future vaccine design.
Details
- Title
- Novel, cross-restricted, conserved, and immunodominant Cytotoxic T Lymphocyte epitopes in slow progressors in HIV Type 1 infection
- Authors/Creators
- P.J.R. Goulder (Author/Creator) - John Radcliffe HospitalM. Bunce (Author/Creator)P. Krausa (Author/Creator)K. McIntyre (Author/Creator)S. Crowley (Author/Creator)B. Morgan (Author/Creator)A. Edwards (Author/Creator)P. Giangrande (Author/Creator)R.E. Phillips (Author/Creator)A.J. McMichael (Author/Creator)
- Publication Details
- AIDS Research and Human Retroviruses, Vol.12(18), pp.1691-1698
- Publisher
- Mary Ann Liebert
- Identifiers
- 991005540832207891
- Copyright
- 1996 Goulder et al.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.66 HIV
- 1.66.46 HIV Pathogenesis
- Web Of Science research areas
- Immunology
- Infectious Diseases
- Virology
- ESI research areas
- Immunology