Journal article
Nuclease resistant methylphosphonate-DNA/LNA chimeric oligonucleotides
Bioorganic & Medicinal Chemistry Letters, Vol.19(10), pp.2707-2709
2009
Abstract
Synthesis of chimeric 9-mer oligonucleotides containing methylphosphonate-linkages and locked nucleic acid (LNA) monomers, their binding affinity towards complementary DNA and RNA, and their 3′-exonucleolytic stability are described. The obtained methylphosphonate-DNA/LNA chimeric oligonucleotides display similarly high RNA affinity and RNA selectivity as a corresponding 9-mer DNA/LNA chimeric oligonucleotide, but much higher resistance towards 3′-exonucleolytic degradation.
Details
- Title
- Nuclease resistant methylphosphonate-DNA/LNA chimeric oligonucleotides
- Authors/Creators
- K. Nagahama (Author/Creator) - University of Southern DenmarkR.N. Veedu (Author/Creator) - University of Southern DenmarkJ. Wengel (Author/Creator) - University of Southern Denmark
- Publication Details
- Bioorganic & Medicinal Chemistry Letters, Vol.19(10), pp.2707-2709
- Publisher
- Elsevier BV
- Identifiers
- 991005542924407891
- Copyright
- © 2009 Elsevier Ltd.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Citation topics
- 2 Chemistry
- 2.170 Nucleic Acids Chemistry
- 2.170.988 Oligonucleotide Modifications
- Web Of Science research areas
- Chemistry, Medicinal
- Chemistry, Organic
- ESI research areas
- Chemistry