Files and links (1)
Open Access CC BY V4.0
Journal article
OGDH mediates α-ketoglutarate-induced follicular development and antioxidative response by interacting with CAT/SOD2
Biological research, Vol.59(1), 33
2026
PMID: 41964037
Abstract
Background
Follicular disorders, often driven by ROS-induced granulosa cell apoptosis, are a major cause of female infertility. While α-ketoglutarate (AKG), also known as 2-oxoglutarate, can improve follicular development, the underlying mechanisms remain unclear. Given that AKG is the primary substrate of oxoglutarate dehydrogenase (OGDH), this study aimed to investigate how OGDH mediates the protective role of AKG against oxidative stress and in supporting follicular development.
Result
AKG treatment advanced puberty onset and increased the number of corpora lutea in mice. It alleviated oxidative stress and apoptosis in granulosa cells by upregulating CAT and downregulating P53. Crucially, OGDH physically interacted with CAT and SOD2 and boosted their enzymatic activities, thereby reinforcing AKG’s antioxidative effects. Knockdown of OGDH markedly impaired the ability of AKG to promote follicular development.
Conclusions
These findings identify OGDH as a key mediator of AKG’s protective role in follicular development through modulation of oxidative stress and apoptosis. This work provides mechanistic insight into AKG function and supports its potential as a therapeutic strategy for follicular disorders.
Details
- Title
- OGDH mediates α-ketoglutarate-induced follicular development and antioxidative response by interacting with CAT/SOD2
- Authors/Creators
- Enyuan Huang - South China Agricultural UniversityJingyu Zhou - South China Agricultural UniversityMengting Hu - South China Agricultural UniversityLiuhong Zhang - South China Agricultural UniversityJiahao Shao - South China Agricultural UniversityMeng Lv - South China Agricultural UniversityFen Miao - South China Agricultural UniversityYao Jiang - Murdoch UniversityNian Li - South China Agricultural UniversityJiaqi Li - South China Agricultural UniversityXiaolong Yuan - South China Agricultural University
- Publication Details
- Biological research, Vol.59(1), 33
- Publisher
- Springer Nature
- Number of pages
- 12
- Grant note
- 2024B03J1305 / Science and Technology Project of Guangzhou 2024A1515012999 / Guangdong Basic and Applied Basic Research Foundation CARS-35 / Earmarked Fund for China Agriculture Research System 2024B1515020112 / Guangdong Basic and Applied Basic Research Foundation 32072694 / National Natural Science Foundation of China 2024CXTD22 / Morden Agricultural Industrial Technology System Innovation Team of Guangdong Province 2023A1515030054 / Guangdong Basic and Applied Basic Research Foundation NCTIP-XDB14 / National Center of Technology Innovation for Pigs
- Identifiers
- 991005888555107891
- Copyright
- © The Author(s) 2026.
- Murdoch Affiliation
- Centre for Healthy Ageing; School of Medical, Molecular and Forensic Sciences
- Language
- English
- Resource Type
- Journal article
Metrics
1 Record Views