Objective monitoring of mTOR inhibitor therapy by Three-Dimensional facial analysis

G.S. Baynam; M. Walters; H. Dawkins; M. Bellgard; A.R. Halbert; P. Claes

doi:10.1017/thg.2013.49

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Objective monitoring of mTOR inhibitor therapy by Three-Dimensional facial analysis

Journal article

Open access

Peer reviewed

Objective monitoring of mTOR inhibitor therapy by Three-Dimensional facial analysis

G.S. Baynam, M. Walters, H. Dawkins, M. Bellgard, A.R. Halbert and P. Claes

Twin Research and Human Genetics, Vol.16(4), pp.840-844

2013

DOI: https://doi.org/10.1017/thg.2013.49

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Abstract

With advances in therapeutics for rare, genetic and syndromic diseases, there is an increasing need for objective assessments of phenotypic endpoints. These assessments will preferentially be high precision, non-invasive, non-irradiating, and relatively inexpensive and portable. We report a case of a child with an extensive lymphatic vascular malformation of the head and neck, treated with an mammalian target of Rapamycin (mTOR) inhibitor that was assessed using 3D facial analysis. This case illustrates that this technology is prospectively a cost-effective modality for treatment monitoring, and it supports that it may also be used for novel explorations of disease biology for conditions associated with disturbances in the mTOR, and interrelated, pathways.

Details

Title: Objective monitoring of mTOR inhibitor therapy by Three-Dimensional facial analysis
Authors/Creators: G.S. Baynam (Author/Creator) - The University of Western Australia
M. Walters (Author/Creator) - Princess Margaret Hospital for Children
H. Dawkins (Author/Creator) - Government of Western Australia Department of Health
M. Bellgard (Author/Creator) - Murdoch University
A.R. Halbert (Author/Creator) - Princess Margaret Hospital for Children
P. Claes (Author/Creator) - KU Leuven
Publication Details: Twin Research and Human Genetics, Vol.16(4), pp.840-844
Publisher: Cambridge University Press
Identifiers: 991005543280107891
Murdoch Affiliation: Centre for Comparative Genomics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.49 Dentistry & Oral Medicine; 1.49.464 Orthodontic Treatment
Web Of Science research areas: Genetics & Heredity; Obstetrics & Gynecology
ESI research areas: Molecular Biology & Genetics