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CC BY-NC-ND V4.0, Open Access
Journal article
Old muscle, new tricks: A clinician perspective on sarcopenia and where to next
Current opinion in neurology, Vol.36(5), pp.441-449
2023
PMID: 37501556
Abstract
Purpose of review: This review offers a contemporary clinical approach to the recognition, prevention and management of sarcopenia, and discusses recent clinically relevant advances in the aetiopathogenesis of muscle ageing that may lead to future therapeutic targets.
Recent findings: The key recent directions for sarcopenia are in the diagnosis, understanding molecular mechanisms and management. Regarding the recognition of the condition, it has become increasingly clear that different definitions hamper progress in understanding. Therefore, the Global Leadership in Sarcopenia has been established in 2022 to develop a universally accepted definition. Moreover, substantial work is occurring to understand the various roles and contribution of inflammation, oxidative stress, mitochondrial dysfunction and metabolic dysregulation on skeletal muscle function and ageing. Finally, the role of resistance-based exercise regimes has been continually emphasised. However, the role of protein supplementation and hormone replacement therapy (HRT) are still under debate, and current clinical trials are underway.
Summary: With the global ageing of our population, there is increasing emphasis on maintaining good health. Maintenance of skeletal muscle strength and function are key to preventing frailty, morbidity and death.
Details
- Title
- Old muscle, new tricks: A clinician perspective on sarcopenia and where to next
- Authors/Creators
- Katie Schütze - The University of Notre Dame AustraliaMadeline Schopp - The University of Notre Dame AustraliaTimothy J. Fairchild - Murdoch University, Centre for Molecular Medicine and Innovative TherapeuticsMerrilee Needham - Murdoch University, Centre for Molecular Medicine and Innovative Therapeutics
- Publication Details
- Current opinion in neurology, Vol.36(5), pp.441-449
- Publisher
- Wolters Kluwer Health, Inc.
- Identifiers
- 991005602252907891
- Copyright
- © 2023 The Author(s).
- Murdoch Affiliation
- Centre for Molecular Medicine and Innovative Therapeutics; School of Allied Health
- Language
- English
- Resource Type
- Journal article
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- Citation topics
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- 1.44 Nutrition & Dietetics
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- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior