Olfactory discrimination predicts cognitive decline among community-dwelling older adults

H.R. Sohrabi; K.A. Bates; M.G. Weinborn; A.N.B. Johnston; A. Bahramian; K Taddei; S.M. Laws; M. Rodrigues; M. Morici; M. Howard; G. Martins; A. MacKay-Sim; S.E. Gandy; R.N. Martins

doi:10.1038/tp.2012.43

Back

Olfactory discrimination predicts cognitive decline among community-dwelling older adults

Journal article

Peer reviewed

Olfactory discrimination predicts cognitive decline among community-dwelling older adults

H.R. Sohrabi, K.A. Bates, M.G. Weinborn, A.N.B. Johnston, A. Bahramian, K Taddei, S.M. Laws, M. Rodrigues, M. Morici, M. Howard, …

Translational Psychiatry, Vol.2(5), e118

2012

DOI: https://doi.org/10.1038/tp.2012.43

Files and links (1)

url

Link to Published Version *Subscription may be requiredView

Abstract

The presence of olfactory dysfunction in individuals at higher risk of Alzheimer's disease has significant diagnostic and screening implications for preventive and ameliorative drug trials. Olfactory threshold, discrimination and identification can be reliably recorded in the early stages of neurodegenerative diseases. The current study has examined the ability of various olfactory functions in predicting cognitive decline in a community-dwelling sample. A group of 308 participants, aged 46–86 years old, were recruited for this study. After 3 years of follow-up, participants were divided into cognitively declined and non-declined groups based on their performance on a neuropsychological battery. Assessment of olfactory functions using the Sniffin’ Sticks battery indicated that, contrary to previous findings, olfactory discrimination, but not olfactory identification, significantly predicted subsequent cognitive decline (odds ratio=0.869; P<0.05; 95% confidence interval=0.764−0.988). The current study findings confirm previously reported associations between olfactory and cognitive functions, and indicate that impairment in olfactory discrimination can predict future cognitive decline. These findings further our current understanding of the association between cognition and olfaction, and support olfactory assessment in screening those at higher risk of dementia.

Details

Title: Olfactory discrimination predicts cognitive decline among community-dwelling older adults
Authors/Creators: H.R. Sohrabi (Author/Creator) - Edith Cowan University
K.A. Bates (Author/Creator) - The University of Western Australia
M.G. Weinborn (Author/Creator) - The University of Western Australia
A.N.B. Johnston (Author/Creator)
A. Bahramian (Author/Creator) - Hollywood Private Hospital
K Taddei (Author/Creator) - Edith Cowan University
S.M. Laws (Author/Creator) - Hollywood Private Hospital
M. Rodrigues (Author/Creator) - Hollywood Private Hospital
M. Morici (Author/Creator) - Edith Cowan University
M. Howard (Author/Creator) - Edith Cowan University
G. Martins (Author/Creator) - Edith Cowan University
A. MacKay-Sim (Author/Creator) - Griffith University
S.E. Gandy (Author/Creator) - Icahn School of Medicine at Mount Sinai
R.N. Martins (Author/Creator) - Edith Cowan University
Publication Details: Translational Psychiatry, Vol.2(5), e118
Publisher: Macmillan Publishers Limited
Identifiers: 991005545445207891
Copyright: © 2020 Springer Nature Limited
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

39 Record Views

101 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Citation topics: 3 Agriculture, Environment & Ecology; 3.220 Smell & Taste Science; 3.220.701 Olfactory Systems
Web Of Science research areas: Psychiatry
ESI research areas: Psychiatry/Psychology