Journal article
Olfactory dysfunction is associated with subjective memory complaints in community-dwelling elderly individuals
Journal of Alzheimer's disease : JAD, Vol.17(1), pp.135-142
2009
Abstract
Olfactory dysfunction has been reported in clinical and preclinical phases of Alzheimer's disease. Subjective memory complaints have been proposed as a potential early indicator for increased risk of Alzheimer's disease, but have also been associated with depression, personality characteristics, and health problems. In this study, we aimed to determine which of these putative markers can predict memory complaints in community-dwelling elderly individuals, focusing on olfactory symptoms. A cohort of 144 elderly volunteers (42 males and 102 females), aged 50 to 86, was recruited from an ongoing longitudinal study. Participants were assessed for olfactory capacities (threshold, discrimination, and identification), subjective memory complaints, depression, and cognitive functions. Subjective memory complaints were significantly associated with olfactory discrimination and identification but not with threshold. Olfactory functions and depressive symptoms were both significantly associated with subjective memory complaints. In addition, memory complainers were significantly worse than non-complainers with respect to olfactory discrimination, identification, and overall olfactory functioning. The findings suggest that olfactory capacity may be a potentially significant biomarker for identifying community-dwelling elderly with memory complaints who are at increased risk for age-related cognitive decline and Alzheimer's disease.
Details
- Title
- Olfactory dysfunction is associated with subjective memory complaints in community-dwelling elderly individuals
- Authors/Creators
- H.R. Sohrabi (Author/Creator) - The University of Western AustraliaK.A. Bates (Author/Creator) - School of Psychiatry and Clinical NeurosciencesM. Rodrigues (Author/Creator) - School of Psychiatry and Clinical NeurosciencesK. Taddei (Author/Creator) - Edith Cowan UniversityS.M. Laws (Author/Creator) - Technical University MunichN.T. Lautenschlager (Author/Creator) - School of Psychiatry and Clinical NeurosciencesS.S. Dhaliwal (Author/Creator) - Curtin UniversityA.N.B. Johnston (Author/Creator) - Griffith UniversityA. MacKay-Sim (Author/Creator) - Griffith UniversityS. Gandy (Author/Creator) - Icahn School of Medicine at Mount SinaiJ.K. Foster (Author/Creator) - School of Paediatrics and Child HealthR.N. Martins (Author/Creator) - School of Psychiatry and Clinical Neurosciences
- Publication Details
- Journal of Alzheimer's disease : JAD, Vol.17(1), pp.135-142
- Publisher
- IOS Press
- Identifiers
- 991005544242207891
- Copyright
- © 2009 IOS Press
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 3 Agriculture, Environment & Ecology
- 3.220 Smell & Taste Science
- 3.220.701 Olfactory Systems
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior