Journal article
On the choice of mathematical models for the estimation of lethal gene equivalents in man
Heredity, Vol.57(3), pp.377-380
1986
Abstract
A range of mathematical models and error distributions was used to examine the validity of linear regression methods for the calculation of lethal gene equivalents. Because of the restricted span of inbreeding coefficient F values available in human studies and the limited number of data points, equivalent results were obtained with all combinations tested. It was concluded that linear regressions should be employed only for the detection of significant inbreeding effects in man and that their application to the estimation of lethal gene equivalents was not warranted.
Details
- Title
- On the choice of mathematical models for the estimation of lethal gene equivalents in man
- Authors/Creators
- E. Makov (Author/Creator) - Queen Mary University of LondonA.H. Bittles (Author/Creator) - Department of Anatomy and Human Biology, King's College, Strand, London, UK
- Publication Details
- Heredity, Vol.57(3), pp.377-380
- Publisher
- Nature Publishing Group
- Identifiers
- 991005542457107891
- Copyright
- 1986 The Genetical Society of Great Britain
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.189 Genome Studies
- 1.189.1853 Human Genetic Diversity
- Web Of Science research areas
- Ecology
- Evolutionary Biology
- Genetics & Heredity
- ESI research areas
- Molecular Biology & Genetics