Journal article
Oncostatin M induces an acute phase response but does not modulate the growth or maturation-status of liver progenitor (oval) cells in culture
Experimental Cell Research, Vol.306(1), pp.252-263
2005
Abstract
Following acute injury, the liver regenerates through hepatocyte division. If this pathway is impaired, liver repair depends on the recruitment of adult liver progenitor (oval) cells. Mice fed a choline deficient, ethionine supplemented (CDE) diet possess substantial numbers of oval cells, which can be isolated, or examined in vivo. Oncostatin M (OSM) has been shown to induce maturation of murine fetal hepatoblasts into hepatocytes. We recently confirmed this in human fetal liver cultures. Here, we show that liver OSM expression increases in mice fed a CDE diet and CDE-derived oval cell isolates express OSM and its receptor (OSMR). Oval cell lines (PIL cells), as well as primary oval cell cultures, displayed STAT-3 phosphorylation following OSM stimulation. OSM had no effect on the growth of primary oval cells, but it was pro-apoptotic to PIL cells, suggesting that the two cell models are not directly comparable. Expression of PCNA and cyclin D1 was not affected by OSM treatment. No evidence was obtained to suggest an effect on oval cell maturation with OSM treatment. However, decreased albumin production, accompanied by increased expression of haptoglobin and fibrinogen, suggests that OSM induced an acute phase reaction in cultured oval cells.
Details
- Title
- Oncostatin M induces an acute phase response but does not modulate the growth or maturation-status of liver progenitor (oval) cells in culture
- Authors/Creators
- V.B. Matthews (Author/Creator)B. Knight (Author/Creator) - The University of Western AustraliaJ.E.E. Tirnitz-Parker (Author/Creator) - The University of Western AustraliaJ. Boon (Author/Creator) - The University of Western AustraliaJ.K. Olynyk (Author/Creator) - The University of Western AustraliaG.C.T. Yeoh (Author/Creator) - The University of Western Australia
- Publication Details
- Experimental Cell Research, Vol.306(1), pp.252-263
- Publisher
- Elsevier
- Identifiers
- 991005539586407891
- Copyright
- 2005 Elsevier Inc.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.102 Stem Cell Research
- 1.102.1150 Hepatocyte Growth Factor
- Web Of Science research areas
- Cell Biology
- Oncology
- ESI research areas
- Molecular Biology & Genetics