Ontogeny of Toll-Like and NOD-Like Receptor-Mediated innate immune responses in Papua New Guinean infants

J.G. Lisciandro; S.L. Prescott; M.G. Nadal-Sims; C.J. Devitt; W. Pomat; P.M. Siba; M.C. Tulic; P.G. Holt; D. Strickland; A.H.J. van den Biggelaar

doi:10.1371/journal.pone.0036793

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Ontogeny of Toll-Like and NOD-Like Receptor-Mediated innate immune responses in Papua New Guinean infants

Journal article

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Ontogeny of Toll-Like and NOD-Like Receptor-Mediated innate immune responses in Papua New Guinean infants

J.G. Lisciandro, S.L. Prescott, M.G. Nadal-Sims, C.J. Devitt, W. Pomat, P.M. Siba, M.C. Tulic, P.G. Holt, D. Strickland and A.H.J. van den Biggelaar

PloS one, Vol.7(5)

2012

DOI: https://doi.org/10.1371/journal.pone.0036793

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Abstract

Studies addressing the ontogeny of the innate immune system in early life have reported mainly on Toll-like receptor (TLR) responses in infants living in high-income countries, with little or even no information on other pattern recognition receptors or on early life innate immune responses in children living under very different environmental conditions in less-developed parts of the world. In this study, we describe whole blood innate immune responses to both Toll-like and nucleotide-binding oligomerization domain (NOD)-like receptor agonists including the widely used vaccine adjuvant ‘alum’ in a group of Papua New Guinean infants aged 1–3 (n = 18), 4–6 (n = 18), 7–12 (n = 21) and 13–18 (n = 10) months old. Depending on the ligands and cytokines studied, different age-related patterns were found: alum-induced IL-1β and CXCL8 responses were found to significantly decline with increasing age; inflammatory (IL-6, IL-1β, IFN-γ) responses to TLR2 and TLR3 agonists increased; and IL-10 responses remained constant or increased during infancy, while TNF-α responses either declined or remained the same. We report for the first time that whole blood innate immune responses to the vaccine adjuvant alum decrease with age in infancy; a finding that may imply that the adjuvant effect of alum in pediatric vaccines could be age-related. Our findings further suggest that patterns of innate immune development may vary between geographically diverse populations, which in line with the ‘hygiene hypothesis’ particularly involves persistence of innate IL-10 responses in populations experiencing higher infectious pressure.

Details

Title: Ontogeny of Toll-Like and NOD-Like Receptor-Mediated innate immune responses in Papua New Guinean infants
Authors/Creators: J.G. Lisciandro (Author/Creator)
S.L. Prescott (Author/Creator)
M.G. Nadal-Sims (Author/Creator)
C.J. Devitt (Author/Creator)
W. Pomat (Author/Creator)
P.M. Siba (Author/Creator)
M.C. Tulic (Author/Creator)
P.G. Holt (Author/Creator)
D. Strickland (Author/Creator)
A.H.J. van den Biggelaar (Author/Creator)
Publication Details: PloS one, Vol.7(5)
Publisher: Public Library of Science
Identifiers: 991005544557707891
Copyright: © 2012 Lisciandro et al.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.609 Toll-like Receptors
Web Of Science research areas: Immunology
ESI research areas: Immunology