Oocyte exposure to ZnO nanoparticles inhibits early embryonic development through the γ-H2AX and NF-κB signaling pathways

J. Liu; Y. Zhao; W. Ge; P. Zhang; X. Liu; W. Zhang; Y. Hao; S. Yu; L. Li; M. Chu; L. Min; H. Zhang; W. Shen

doi:10.18632/oncotarget.17349

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Oocyte exposure to ZnO nanoparticles inhibits early embryonic development through the γ-H2AX and NF-κB signaling pathways

Journal article

Open access

Peer reviewed

Oocyte exposure to ZnO nanoparticles inhibits early embryonic development through the γ-H2AX and NF-κB signaling pathways

J. Liu, Y. Zhao, W. Ge, P. Zhang, X. Liu, W. Zhang, Y. Hao, S. Yu, L. Li, M. Chu, …

Oncotarget, Vol.8(26), pp.42673-42692

2017

DOI: https://doi.org/10.18632/oncotarget.17349

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Abstract

The impacts of zinc oxide nanoparticles on embryonic development following oocyte stage exposure are unknown and the underlying mechanisms are sparsely understood. In the current investigation, intact nanoparticles were detected in ovarian tissue in vivo and cultured cells in vitro under zinc oxide nanoparticles treatment. Zinc oxide nanoparticles exposure during the oocyte stage inhibited embryonic development. Notably, in vitro culture data closely matched in vivo embryonic data, in that the impairments caused by Zinc oxide nanoparticles treatment passed through cell generations; and both gamma-H2AX and NF-kappaB pathways were involved in zinc oxide nanoparticles caused embryo-toxicity. Copper oxide and silicon dioxide nanoparticles have been used to confirm that particles are important for the toxicity of zinc oxide nanoparticles. The toxic effects of zinc oxide nanoparticles emanate from both intact nanoparticles and Zn2+. Our investigation along with others suggests that zinc oxide nanoparticles are toxic to the female reproductive system [ovaries (oocytes)] and subsequently embryo-toxic and that precaution should be taken regarding human exposure to their everyday use.

Details

Title: Oocyte exposure to ZnO nanoparticles inhibits early embryonic development through the γ-H2AX and NF-κB signaling pathways
Authors/Creators: J. Liu (Author/Creator) - Qingdao Agricultural University
Y. Zhao (Author/Creator) - Qingdao Agricultural University
W. Ge (Author/Creator) - Qingdao Agricultural University
P. Zhang (Author/Creator) - Qingdao Agricultural University
X. Liu (Author/Creator) - Qingdao Agricultural University
W. Zhang (Author/Creator) - Qingdao Agricultural University
Y. Hao (Author/Creator) - Qingdao Agricultural University
S. Yu (Author/Creator) - Qingdao Agricultural University
L. Li (Author/Creator) - Qingdao Agricultural University
M. Chu (Author/Creator) - Qingdao Agricultural University
L. Min (Author/Creator) - Qingdao Agricultural University
H. Zhang (Author/Creator) - State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, P. R. China.
W. Shen (Author/Creator) - Qingdao Agricultural University
Publication Details: Oncotarget, Vol.8(26), pp.42673-42692
Publisher: Impact Journals
Identifiers: 991005540487707891
Copyright: © 2017 Liu et al.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 2 Chemistry; 2.67 Nanoparticles; 2.67.231 Nanotoxicology
Web Of Science research areas: Cell Biology; Oncology
ESI research areas: Molecular Biology & Genetics