Opioid antagonist naloxone potentiates anxiogenic-like action of cholecystokinin agonists in elevated plus-maze

S. Kõks; A. Soosaar; V. Võikar; V. Volke; M. Ustav; P.T. Männistö; M. Bourin; E. Vasar

doi:10.1016/S0143-4179(98)90042-7

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Opioid antagonist naloxone potentiates anxiogenic-like action of cholecystokinin agonists in elevated plus-maze

Journal article

Peer reviewed

Opioid antagonist naloxone potentiates anxiogenic-like action of cholecystokinin agonists in elevated plus-maze

S. Kõks, A. Soosaar, V. Võikar, V. Volke, M. Ustav, P.T. Männistö, M. Bourin and E. Vasar

Neuropeptides, Vol.32(3), pp.235-240

1998

DOI: https://doi.org/10.1016/S0143-4179(98)90042-7

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Abstract

This study investigated the interplay of cholecystokinin (CCK) and endogenous opioid peptides in the regulation of anxiety. The acute administration of non-selective CCK agonist caerulein (1 and 5 μg/kg) and a selective CCKB receptor agonist BOC-CCK-4 (1, 10 and 50 μg/kg) induced a dose-dependent anxiogenic-like action in the plus-maze model of anxiety. BOC-CCK-4 displayed a similar efficacy with caerulein, indicating that the described effect was mediated via CCKB receptor subtype. The opioid antagonist naloxone itself (0.5 mg/kg) did not change the exploratory activity of rats in the plus-maze. However, the combination of naloxone with the sub-effective doses of caerulein (1 μg/kg) and BOC-CCK-4 (1 μg/kg) induced a significant inhibition of exploratory behaviour in rats. Accordingly, CCK and endogenous opioid peptides have an antagonistic role in the exploratory model of anxiety in rats.

Details

Title: Opioid antagonist naloxone potentiates anxiogenic-like action of cholecystokinin agonists in elevated plus-maze
Authors/Creators: S. Kõks (Author/Creator) - University of Tartu
A. Soosaar (Author/Creator) - University of Tartu
V. Võikar (Author/Creator) - University of Tartu
V. Volke (Author/Creator) - University of Tartu
M. Ustav (Author/Creator) - University of Tartu
P.T. Männistö (Author/Creator) - University of Eastern Finland
M. Bourin (Author/Creator) - Nantes Université
E. Vasar (Author/Creator) - University of Tartu
Publication Details: Neuropeptides, Vol.32(3), pp.235-240
Publisher: Elsevier
Identifiers: 991005541127307891
Copyright: © 1998 Elsevier Ltd.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.195 Neuroendocrine & Intestinal Disorders; 1.195.1096 Gastrin/CCK Functions
Web Of Science research areas: Endocrinology & Metabolism; Neurosciences
ESI research areas: Neuroscience & Behavior