Journal article
Optimizing antenatal corticosteroid therapy
Seminars in Fetal and Neonatal Medicine, Vol.24(3), pp.176-181
2019
Abstract
Treatment with antenatal corticosteroids (ACS) is standard of care for women at risk of preterm birth between 24-34 weeks’ gestation. ACS are increasingly used for other indications, including threated or indicated late preterm birth, elective cesarean, and in at-risk pregnancies for periviable gestations. However, the various drugs and doses being used worldwide have not been rigorously evaluated to optimize clinical responses and to minimize potential risks. Translational research in animal models indicate that a constant, low concentration fetal exposure to ACS is sufficient for lung maturation, resulting in lower fetal exposures. Clinical trials to develop dosing strategies with inexpensive and widely available drugs could promote greater use in low resource environments.
Details
- Title
- Optimizing antenatal corticosteroid therapy
- Authors/Creators
- M.W. Kemp (Author/Creator) - Tohoku University HospitalA.F. Schmidt (Author/Creator) - Cincinnati Children's Hospital Medical CenterA.H. Jobe (Author/Creator) - Cincinnati Children's Hospital Medical Center
- Publication Details
- Seminars in Fetal and Neonatal Medicine, Vol.24(3), pp.176-181
- Publisher
- Elsevier Ltd
- Identifiers
- 991005542106407891
- Copyright
- © 2019 Published by Elsevier Ltd.
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.72 Obstetrics & Gynecology
- 1.72.924 Preterm Birth Causes
- Web Of Science research areas
- Pediatrics
- ESI research areas
- Clinical Medicine