Journal article
Oral delivery of the appetite suppressing peptide hPYY(3-36) through the Vitamin B12 uptake pathway
Journal of Medicinal Chemistry, Vol.54(24), pp.8707-8711
2011
Abstract
hPYY(3-36) injections have shown positive effects on appetite regulations, sparking increased interest in hPYY(3-36) research. Of great interest is oral delivery of hPYY(3-36) that can achieve clinically relevant weight-loss outcomes in what would be a highly patient compliant route. Successful oral delivery of other peptides utilizing the vitamin B12 pathway has been shown but below clinically relevant levels. Herein, we present clinically relevant in vivo oral delivery of B12-hPYY(3-36) conjugates.
Details
- Title
- Oral delivery of the appetite suppressing peptide hPYY(3-36) through the Vitamin B12 uptake pathway
- Authors/Creators
- C.H. Fazen (Author/Creator) - Syracuse UniversityD. Valentin (Author/Creator) - Syracuse UniversityT.J. Fairchild (Author/Creator) - Murdoch UniversityR.P. Doyle (Author/Creator) - Syracuse University
- Publication Details
- Journal of Medicinal Chemistry, Vol.54(24), pp.8707-8711
- Publisher
- American Chemical Society
- Identifiers
- 991005544150007891
- Murdoch Affiliation
- School of Chiropractic and Sports Science
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.26 Diabetes
- 1.26.337 Appetite Hormones
- Web Of Science research areas
- Chemistry, Medicinal
- ESI research areas
- Chemistry