Organ-specific crystalline structures of ferritin cores in β- thalassemia/hemoglobin E

T.G. St Pierre; K.C. Tran; J. Webb; D.J. Macey; B.R Heywood; N.H. Sparks; V.J. Wade; S. Manna; P. Pootrakul

doi:10.1007/BF01141308

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Organ-specific crystalline structures of ferritin cores in β- thalassemia/hemoglobin E

Journal article

Peer reviewed

Organ-specific crystalline structures of ferritin cores in β- thalassemia/hemoglobin E

T.G. St Pierre, K.C. Tran, J. Webb, D.J. Macey, B.R Heywood, N.H. Sparks, V.J. Wade, S. Manna and P. Pootrakul

Biology of Metals, Vol.4(3), pp.162-165

1991

DOI: https://doi.org/10.1007/BF01141308

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Abstract

The cores of ferritins isolated from different organs of human subjects with β-thalassemia/hemoglobin E (β-thal/HbE) disease have different size distributions and crystallinities depending on the source organ. These patients have not been treated by hypertransfusion regimen or iron chelation therapy. β-Thal/HbE spleens and livers yield ferritin cores which are less crystalline than those isolated from normal spleens and livers, reflecting the more rapid deposition of iron in the diseased state. Ferritins isolated from the hearts and pancreases of β-thal/HbE subjects were found to have larger, more crystalline cores than those from the β-thal/HbE livers and spleens, possibly as a consequence of the role of the heart and pancreas as long-term iron deposition sites in this iron overload pathology.

Details

Title: Organ-specific crystalline structures of ferritin cores in β- thalassemia/hemoglobin E
Authors/Creators: T.G. St Pierre (Author/Creator)
K.C. Tran (Author/Creator) - Murdoch University
J. Webb (Author/Creator) - Murdoch University
D.J. Macey (Author/Creator) - Murdoch University
B.R Heywood (Author/Creator) - University of Bath
N.H. Sparks (Author/Creator) - University of Bath
V.J. Wade (Author/Creator) - University of Bath
S. Manna (Author/Creator) - University of Bath
P. Pootrakul (Author/Creator) - Mahidol University
Publication Details: Biology of Metals, Vol.4(3), pp.162-165
Publisher: Springer-Verlag
Identifiers: 991005541365407891
Copyright: © 1991 Springer-Verlag
Murdoch Affiliation: School of Biological and Environmental Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.184 Physiology & Metals; 1.184.573 Iron Metabolism
Web Of Science research areas: Biochemistry & Molecular Biology; Biology
ESI research areas: Biology & Biochemistry