Outer membrane protein 25-a mitochondrial anchor and inhibitor of stress-activated protein kinase-3

N.W. Court; E. Ingley; S.P. Klinken; M.A. Bogoyevitch

doi:10.1016/j.bbamcr.2004.11.008

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Outer membrane protein 25-a mitochondrial anchor and inhibitor of stress-activated protein kinase-3

Journal article

Peer reviewed

Outer membrane protein 25-a mitochondrial anchor and inhibitor of stress-activated protein kinase-3

N.W. Court, E. Ingley, S.P. Klinken and M.A. Bogoyevitch

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol.1744(1), pp.68-75

2005

DOI: https://doi.org/10.1016/j.bbamcr.2004.11.008

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Abstract

Stress-activated protein kinase-3 (SAPK3) is unique amongst the mitogen-activated protein kinase (MAPK) family with its C-terminal 5 amino acids directing interaction with the PDZ domain-containing substrates α1-Syntrophin and SAP90/PSD95. Here, we identify three additional PDZ domain-containing binding partners, Lin-7C, Scribble, and outer membrane protein 25 (OMP25). This latter protein is localised together with SAPK3 at the mitochondria but it is not a SAPK3 substrate. Instead, OMP25 inhibits SAPK3 activity towards PDZ domain-containing substrates such as α1-Syntrophin and substrates without PDZ domains such as the mitochondrial protein Sab. This is a new mechanism for the regulation of SAPK3 and suggests that its intracellular activity should not be solely assessed by its phosphorylation status.

Details

Title: Outer membrane protein 25-a mitochondrial anchor and inhibitor of stress-activated protein kinase-3
Authors/Creators: N.W. Court (Author/Creator) - The University of Western Australia
E. Ingley (Author/Creator) - The University of Western Australia
S.P. Klinken (Author/Creator) - The University of Western Australia
M.A. Bogoyevitch (Author/Creator) - School of Molecular Sciences
Publication Details: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol.1744(1), pp.68-75
Publisher: Elsevier B.V.
Identifiers: 991005541432007891
Copyright: © 2004 Elsevier B.V.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Citation topics: 1 Clinical & Life Sciences; 1.25 Molecular & Cell Biology - Cancer, Autophagy & Apoptosis; 1.25.887 RAS
Web Of Science research areas: Biochemistry & Molecular Biology; Cell Biology
ESI research areas: Molecular Biology & Genetics