Journal article
Oval cell-mediated liver regeneration: Role of cytokines and growth factors
Journal of Gastroenterology and Hepatology, Vol.18(1), pp.4-12
2003
Abstract
In experimental models, which induce liver damage and simultaneously block hepatocyte proliferation, the recruitment of a hepatic progenitor cell population comprised of oval cells is invariably observed. There is a substantial body of evidence to suggest that oval cells are involved in liver regeneration, as they differentiate into hepatocytes and biliary cells. Recently, bone marrow cells were shown to be a source of a stem cells with the capacity to repopulate the liver. Presently, the relationship between bone marrow cells and oval cells is unclear. Investigations will be greatly assisted by the availability of in vitro models based on a knowledge of cytokines that affect oval cells. While the cytokines, which regulate the different hematopoietic lineages, are well characterized, there is relatively little information regarding those that influence oval cells. This review outlines recent developments in the field of oval cell research and focuses on cytokines and growth factors that have been implicated in regulating oval cell proliferation and differentiation.
Details
- Title
- Oval cell-mediated liver regeneration: Role of cytokines and growth factors
- Authors/Creators
- K.N. Lowes (Author/Creator) - The University of Western AustraliaE.J. Croager (Author/Creator) - The University of Western AustraliaJ.K. Olynyk (Author/Creator) - The University of Western AustraliaL.J. Abraham (Author/Creator) - The University of Western AustraliaG.C.T. Yeoh (Author/Creator) - The University of Western Australia
- Publication Details
- Journal of Gastroenterology and Hepatology, Vol.18(1), pp.4-12
- Publisher
- Wiley-Blackwell
- Identifiers
- 991005542323107891
- Copyright
- © 2003 Blackwell Publishing Asia Pty Ltd
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.102 Stem Cell Research
- 1.102.1150 Hepatocyte Growth Factor
- Web Of Science research areas
- Gastroenterology & Hepatology
- ESI research areas
- Clinical Medicine