Journal article
Paraneoplastic hypoglycemia in a diabetic dog with an insulin growth factor-2-producing mammary carcinoma
Veterinary Clinical Pathology, Vol.39(4), pp.480-484
2010
Abstract
A 6-year-old intact female Labrador Retriever had diabetes mellitus, which had been difficult to control with insulin. The dog also had a solid ductal mammary carcinoma with very rapid growth, which was temporally related to onset of hypoglycemia. Eight months after initial diagnosis of diabetes, the dog had a hypoglycemic crisis. Insulin administration was stopped and serum glucose concentration returned to normal. Three months after discontinuing insulin, another hypoglycemic crisis occurred. During subsequent months, serum glucose concentrations remained at life-threatening levels (1.64-2.12 mmol/L, reference interval 4.44-6.66 mmol/L) simultaneously with an increase in the size of the mammary tumor, which reached a diameter of about 16 cm. At the time of surgery for removal of the tumor serum glucose concentration was 2.20 mmol/L and was then monitored every 3 hours after excision of the tumor. The glucose concentration continued to rise and reached 9.99 mmol/L 12 hours after the removal of the mammary tumor. Immunohistochemical staining demonstrated expression of insulin growth factor-2 by tumor cells, which apparently had caused the hypoglycemia during tumor growth even in a diabetic dog. Hyperglycemia associated with diabetes was pronounced after excision of the tumor and had been masked by the paraneoplastic effect of the tumor.
Details
- Title
- Paraneoplastic hypoglycemia in a diabetic dog with an insulin growth factor-2-producing mammary carcinoma
- Authors/Creators
- G. Rossi (Author/Creator)G. Errico (Author/Creator)P. Perez (Author/Creator)G. Rossi (Author/Creator)S. Paltrinieri (Author/Creator)
- Publication Details
- Veterinary Clinical Pathology, Vol.39(4), pp.480-484
- Publisher
- American Society for Veterinary Clinical Pathology
- Identifiers
- 991005545218407891
- Copyright
- ©2010 American Society for Veterinary Clinical Pathology.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.164 Endocrinology & Metabolism
- 1.164.287 GH/IGF Axis
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science