Journal article
Paraquat reduces the female fertility by impairing the Oocyte maturation in Mice
Frontiers in Cell and Developmental Biology, Vol.8, Art. 631104
2021
Abstract
Paraquat (PQ) is a widely used non-selective and oxidizing herbicide in farmland, orchards, flower nursery, and grassland. Overuse of PQ will accumulate in the body and affect the reproduction in mammals. In this study, we found that PQ could reduce the female fertility by oral administration for 21 days in mice. PQ exposure could impair the nuclear maturation by perturbing the spindle assembly and kinetochore–microtubule attachment to cause the misaligned chromosomes during meiosis. In the meantime, PQ exposure disturbed the mitochondrial distribution and enhanced the level of reactive oxygen species and early apoptosis, which thereby deteriorated the early embryo development. Also, PQ administration could cause some changes in epigenetic modifications such as the level of H3K9me2 and H3K27me3. Therefore, PQ administration reduces the female fertility by impairing the nuclear and cytoplasmic maturation of oocytes in mice.
Details
- Title
- Paraquat reduces the female fertility by impairing the Oocyte maturation in Mice
- Authors/Creators
- Y-L Sun (Author/Creator)X-L Wang (Author/Creator)L-L Yang (Author/Creator)Z-J Ge (Author/Creator)Y. Zhao (Author/Creator)S-M Luo (Author/Creator)W. Shen (Author/Creator)Q-Y Sun (Author/Creator)S. Yin (Author/Creator)
- Publication Details
- Frontiers in Cell and Developmental Biology, Vol.8, Art. 631104
- Publisher
- Frontiers Media
- Identifiers
- 991005543055507891
- Copyright
- © 2021 The Authors.
- Murdoch Affiliation
- College of Science, Health, Engineering and Education
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.81 Reproductive Biology
- 1.81.339 Embryo Development
- Web Of Science research areas
- Cell Biology
- Developmental Biology
- ESI research areas
- Molecular Biology & Genetics