Journal article
Parathyroid hormone receptor 1 (PTHR1) is a prognostic indicator in canine osteosarcoma
Scientific Reports, Vol.10(1)
2020
Abstract
Osteosarcoma (OS) is the most common malignant primary bone tumour in humans and dogs. Several studies have established the vital role of parathyroid hormone-related protein (PTHrP) and its receptor (PTHR1) in bone formation and remodeling. In addition, these molecules play a role in the progression and metastasis of many human tumour types. This study investigated the expression of PTHR1 and PTHrP in canine OS tissues and assessed their prognostic value. Formalin-fixed, paraffin-embedded tissue samples from 50 dogs diagnosed with primary OS were immunolabeled with antibodies specific for PTHR1 and PTHrP. The immunostaining intensity of tumours from patients with OS was correlated with survival time. Both PTHR1 and PTHrP were detected in all OS samples (n = 50). Dogs with OS tumours showing high immunostaining intensity for PTHR1 (n = 36) had significantly shorter survival times (p = 0.028, Log Rank; p = 0.04, Cox regression) when compared with OS that had low immunostaining intensity for PTHR1 (n = 14).PTHrP immunostaining intensity did not correlate with survival time (p > 0.05). The results of this study indicate that increased expression of PTHR1 antigen in canine OS is associated with poor prognosis. This suggests that PTHR1 may be useful as a prognostic indicator in canine OS.
Details
- Title
- Parathyroid hormone receptor 1 (PTHR1) is a prognostic indicator in canine osteosarcoma
- Authors/Creators
- A.A. Al-Khan (Author/Creator) - RMIT UniversityJ.S. Nimmo (Author/Creator) - South Australia PathologyM. Tayebi (Author/Creator) - Western Sydney UniversityS.D. Ryan (Author/Creator) - The University of MelbourneJ.O. Simcock (Author/Creator) - Veterinary Medical CenterR. Tarzi (Author/Creator) - Veterinary Medical CenterC.A. Kuntz (Author/Creator) - Veterinary Medical CenterE.S. Saad (Author/Creator) - RMIT UniversityM.J. Day (Author/Creator) - Murdoch UniversityS.J. Richardson (Author/Creator) - RMIT UniversityJ.A. Danks (Author/Creator) - Austin Health
- Publication Details
- Scientific Reports, Vol.10(1)
- Publisher
- Springer Nature
- Identifiers
- 991005540350407891
- Copyright
- © 2020 Springer Nature Limited
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.80 Bone Diseases
- 1.80.348 Parathyroid Disorders
- Web Of Science research areas
- Multidisciplinary Sciences
- ESI research areas
- Clinical Medicine