Journal article
Pathogenesis of pleural fibrosis
Respirology, Vol.9(4), pp.428-440
2004
Abstract
Pleural fibrosis resembles fibrosis in other tissues and can be defined as an excessive deposition of matrix components that results in the destruction of normal pleural tissue architecture and compromised function. Pleural fibrosis may be the consequence of an organised haemorrhagic effusion, tuberculous effusion, empyema or asbestos-related pleurisy and can manifest itself as discrete localised lesions (pleural plaques) or diffuse pleural thickening and fibrosis. Although the pathogenesis is unknown, it is likely that the complex interactions between resident and inflammatory cells, profibrotic mediators and coagulation, and fibrinolytic pathways are integral to pleural remodelling and fibrosis. It is generally considered that the primary target cell for pleural fibrosis is the subpleural fibroblast. However, increasing evidence suggests that mesothelial cells may also play a significant role in the pathogenesis of this condition, both by initiating inflammatory responses and producing matrix components. A greater understanding of the interactions between pleural and inflammatory cells, cytokines and growth factors, and blood derived proteins is required before adequate therapies can be developed to prevent pleural fibrosis from occurring.
Details
- Title
- Pathogenesis of pleural fibrosis
- Authors/Creators
- S.E. Mutsaers (Author/Creator) - Centre for Asthma, Allergy and Respiratory Research andC.M. Prêle (Author/Creator) - The University of Western AustraliaA.R. Brody (Author/Creator) - Tulane UniversityS. Idell (Author/Creator) - The University of Texas Health Science Center at Tyler
- Publication Details
- Respirology, Vol.9(4), pp.428-440
- Publisher
- Wiley-Blackwell
- Identifiers
- 991005542663207891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.199 Lung Cancer
- 1.199.1048 Pulmonary Ultrasound
- Web Of Science research areas
- Respiratory System
- ESI research areas
- Clinical Medicine