Journal article
Patient characteristics and concerns about drug allergy: A report from the United States drug allergy registry
The Journal of Allergy and Clinical Immunology: In Practice, Vol.8(9), pp.2958-2967
2020
Abstract
Background
Drug allergy is frequently reported, but uncommonly confirmed with diagnostic testing. Although drug allergy assessments can improve clinical care, patient concerns may impact the optimal diagnostic approach and/or the clinical effectiveness of diagnostic testing.
Objective
To assess drug allergy patient concerns.
Methods
Using data from a multi-site, prospective longitudinal cohort study, the United States Drug Allergy Registry (01/16/2019-01/24/2020), we determined patient self-reported characteristics and qualitatively coded free-text patient concerns about their drug allergy/allergies. We assessed associations between patient characteristics and drug allergy concerns using multinomial logistic regression models.
Results
Of 592 patients (age 49 [Standard Deviation 17] years, 74% Female, 88% white), the most commonly reported drug allergies were penicillins (78%), cephalosporins (12%) and sulfonamides (12%) with common reactions of rash (62%), hives (54%), itching (48%), flushing or facial redness (28%), and swelling or angioedema (24%). Patient concerns, coded from free-text, were optimal medication use (41%), no concern (17%), allergic reaction (14%), diagnosis (12%), and severe allergic reaction (12%). Using multinomial regression, the presence of drug allergy concerns increased with greater age, higher number of reported drug reactions, more antibiotic use, and certain reaction symptoms, most notably mouth or palate itching. Female sex was associated with increased severe allergic reaction concern. Poorer general and mental health was associated with increased allergic reaction concern.
Conclusion
Drug allergy patients were concerned about their options for medical treatment, having an allergic reaction, and receiving clarity about their diagnosis. Capturing and addressing patient concerns may improve the approach to drug allergy patients and/or the effectiveness of drug allergy testing.
Details
- Title
- Patient characteristics and concerns about drug allergy: A report from the United States drug allergy registry
- Authors/Creators
- K.G. Blumenthal (Author/Creator)T. Harkness (Author/Creator)E.J. Phillips (Author/Creator)A. Ramsey (Author/Creator)A. Banerji (Author/Creator)U. Samarakoon (Author/Creator)C. Stone (Author/Creator)X. Fu (Author/Creator)D.A. Khan (Author/Creator)I. Otani (Author/Creator)C.A. Camargo (Author/Creator)Y. Zhang (Author/Creator)K. Donelan (Author/Creator)
- Publication Details
- The Journal of Allergy and Clinical Immunology: In Practice, Vol.8(9), pp.2958-2967
- Publisher
- Elsevier
- Identifiers
- 991005541095907891
- Copyright
- © 2020 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.265 Dermatology - Skin Allergies
- 1.265.1140 Drug Hypersensitivity
- Web Of Science research areas
- Allergy
- Immunology
- ESI research areas
- Clinical Medicine