Journal article
Perfluorooctanoic acid effects on ovaries mediate its inhibition of peripubertal mammary gland development in Balb/c and C57Bl/6 mice
Reproductive Toxicology, Vol.33(4), pp.563-576
2012
Abstract
Exposure to perfluorooctanoic acid (PFOA), a synthetic perfluorinated compound and an agonist of peroxisome proliferator-activated receptor α (PPARα), causes stunted mouse mammary gland development in various developmental stages. However, the underlying mechanisms remain poorly understood. We found that peripubertal PFOA exposure significantly inhibited mammary gland growth in both Balb/c and C57Bl/6 wild type mice, but not in C57Bl/6 PPARα knockout mice, and Balb/c mice were more sensitive to PFOA inhibition. PFOA caused (1) delayed or absence of vaginal opening and lack of estrous cycling during the experimental period; (2) decreases in ovarian steroid hormonal synthetic enzyme levels; and (3) reduced expression of estrogen- or progesterone-induced mammary growth factors. Supplementation with exogenous estrogen and/or progesterone reversed the PFOA inhibitory effect on mammary gland. These results indicate that PFOA effects on ovaries mediate its inhibition of mammary gland development in Balb/c and C57Bl/6 mice and that PPARα expression is a contributing factor.
Details
- Title
- Perfluorooctanoic acid effects on ovaries mediate its inhibition of peripubertal mammary gland development in Balb/c and C57Bl/6 mice
- Authors/Creators
- Y. Zhao (Author/Creator) - Michigan State UniversityY.S. Tan (Author/Creator) - Michigan State UniversityM.J. Strynar (Author/Creator) - Research Triangle Park FoundationG. Pérez (Author/Creator) - Michigan State UniversityS.Z. Haslam (Author/Creator) - Michigan State UniversityC. Yang (Author/Creator) - Michigan State University
- Publication Details
- Reproductive Toxicology, Vol.33(4), pp.563-576
- Publisher
- Elsevier Inc
- Identifiers
- 991005544174507891
- Copyright
- © 2012 Elsevier Inc
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 3 Agriculture, Environment & Ecology
- 3.60 Herbicides, Pesticides & Ground Poisoning
- 3.60.1998 PFAS Toxicity
- Web Of Science research areas
- Reproductive Biology
- Toxicology
- ESI research areas
- Pharmacology & Toxicology