Journal article
Periodontal attachment loss in HIV-infected patients is associated with the major histocompatibility complex 8.1 haplotype (HLA-A1,B8,DR3)
Tissue Antigens, Vol.54(4), pp.391-399
1999
Abstract
Periodontal attachment loss is mediated by overproduction of tumour necrosis factor (TNF) and interleukin (IL)-1, and appears to have a genetic component. The 8.1 major histocompatibility complex (MHC) ancestral haplotype (HLA-A1,B8,TNFA-308(2),DR3) is associated with elevated TNF production and predisposes carriers to several autoimmune/immunopathological disorders, including rapid progression of HIV disease, but not early onset periodontal disease in healthy individuals. Rather a high proportion of subjects with severe periodontal disease carry allele 2 at IL-1A-889 and IL-1B+3953. We predicted that genetic associations may be different or clearer in HIV patients, as they often show elevated production of TNF and IL-1 and periodontal attachment loss. Hence periodontal parameters and IL-1 polymorphisms were assessed in HIV-positive subjects expressing HLA-B8 with or without other markers of the 8.1 haplotype. Of 16 HLA-B8 subjects, 13 demonstrated elevated probing pocket depth and clinical attachment loss. The difference was statistically significant and did not correlate with smoking, age, CD4 T-cell counts, HIV viral load or levels of dental plaque. As TNFA-308 (allele 2) was present in four non-B8 subjects who had minimal attachment loss, it may not mediate the effect of the 8.1 haplotype. Moreover, polymorphisms at IL-1A-889 and IL-1B+3953 did not significantly affect periodontal parameters. Thus a central MHC gene characteristic of the 8.1 haplotype was the clearest determinant of periodontal attachment loss in HIV-infected individuals.xm.
Details
- Title
- Periodontal attachment loss in HIV-infected patients is associated with the major histocompatibility complex 8.1 haplotype (HLA-A1,B8,DR3)
- Authors/Creators
- P. Price (Author/Creator) - Royal Perth HospitalD.M. Calder (Author/Creator) - The University of Western AustraliaC.S. Witt (Author/Creator) - Royal Perth HospitalR.J.N. Allcock (Author/Creator) - Royal Perth HospitalF.T. Christiansen (Author/Creator) - Faculty (United Kingdom)G.R. Davies (Author/Creator) - The University of Western AustraliaP.U. Cameron (Author/Creator) - The University of MelbourneM. Rogers (Author/Creator) - Royal Perth HospitalK. Baluchova (Author/Creator)C.B. Moore (Author/Creator) - Murdoch UniversityM.A. French (Author/Creator) - Royal Perth Hospital
- Publication Details
- Tissue Antigens, Vol.54(4), pp.391-399
- Publisher
- Blackwell Publishing
- Identifiers
- 991005540321207891
- Murdoch Affiliation
- School of Mathematical and Physical Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.49 Dentistry & Oral Medicine
- 1.49.394 Periodontal Microbiome
- Web Of Science research areas
- Cell Biology
- Immunology
- Pathology
- ESI research areas
- Molecular Biology & Genetics