Peripheral cellular and humoral responses to infestation with the cattle tickRhipicephalus microplusin Santa Gertrudis cattle

E.K. Piper; N.N. Jonsson; C. Gondro; M.E. Vance; A. Lew-Tabor; L.A. Jackson

doi:10.1111/pim.12402

Back

Peripheral cellular and humoral responses to infestation with the cattle tickRhipicephalus microplusin Santa Gertrudis cattle

Journal article

Peer reviewed

Peripheral cellular and humoral responses to infestation with the cattle tickRhipicephalus microplusin Santa Gertrudis cattle

E.K. Piper, N.N. Jonsson, C. Gondro, M.E. Vance, A. Lew-Tabor and L.A. Jackson

Parasite Immunology, Vol.39(1), e12402

2017

DOI: https://doi.org/10.1111/pim.12402

Files and links (1)

url

Link to Published Version *Subscription may be requiredView

Abstract

Resistance to cattle tick infestation in single-host ticks is primarily manifested against the larval stage and results in the immature tick failing to attach successfully and obtain a meal. This study was conducted to identify immune responses that characterize the tick-resistant phenotype in cattle. Thirty-five tick-naïve Santa Gertrudis heifers were used in this study, thirty of which were artificially infested for thirteen weeks with tick larvae while five animals remained at a tick-free quarantine property to serve as a control group. Following thirteen weeks of tick infestation, the animals in this trial exhibited highly divergent tick-resistant phenotypes. Blood samples collected throughout the trial were used to measure peripheral immune parameters: haematology, the percentage of cellular subsets comprising the peripheral blood mononuclear cell (PBMC) population, tick-specific IgG1 and IgG2 antibody titres, IgG1 avidity for tick antigens and the ability of PBMC to recognize and proliferate in response to stimulation with tick antigens in vitro. The tick-susceptible cattle developed significantly higher tick-specific IgG1 antibody titres compared to the tick-resistant animals. These results suggest that the heightened antibody response either does not play a role in resistance or might contribute to increased susceptibility to infestation.

Details

Title: Peripheral cellular and humoral responses to infestation with the cattle tickRhipicephalus microplusin Santa Gertrudis cattle
Authors/Creators: E.K. Piper (Author/Creator) - The University of Queensland
N.N. Jonsson (Author/Creator) - University of Glasgow
C. Gondro (Author/Creator) - University of New England
M.E. Vance (Author/Creator) - Department of Primary Industries
A. Lew-Tabor (Author/Creator) - Department of Primary Industries
L.A. Jackson (Author/Creator) - Department of Primary Industries
Publication Details: Parasite Immunology, Vol.39(1), e12402
Publisher: Blackwell Publishing Inc.
Identifiers: 991005545143807891
Copyright: © 2016 John Wiley & Sons Ltd
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

25 Record Views

19 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.258 Zoonotic Diseases; 1.258.227 Tick-borne Pathogens
Web Of Science research areas: Immunology; Parasitology
ESI research areas: Immunology