Persistence of Clostridium difficile RT 237 infection in a Western Australian piggery

P. Moono; P. Putsathit; D.R. Knight; M.M. Squire; D.J. Hampson; N.F. Foster; T.V. Riley

doi:10.1016/j.anaerobe.2015.11.012

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Persistence of Clostridium difficile RT 237 infection in a Western Australian piggery

Journal article

Open access

Peer reviewed

Persistence of Clostridium difficile RT 237 infection in a Western Australian piggery

P. Moono, P. Putsathit, D.R. Knight, M.M. Squire, D.J. Hampson, N.F. Foster and T.V. Riley

Anaerobe, Vol.37, pp.62-66

2016

DOI: https://doi.org/10.1016/j.anaerobe.2015.11.012

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Abstract

Clostridium difficile is commonly associated with healthcare-related infections in humans, and is an emerging pathogen in food animal species. There is potential for transmission of C. difficile from animals or animal products to humans. This study aimed to determine if C. difficile RT 237 had persisted in a Western Australian piggery or if there had been a temporal change in C. difficile diversity. C. difficile carriage in litters with and without diarrhea was investigated, as was the acquisition of C. difficile over time using cohort surveys. Rectal swabs were obtained from piglets aged 1-10 days to determine prevalence of C. difficile carriage and samples were obtained from 20 piglets on days 1, 7, 13, 20, and 42 of life to determine duration of shedding. Isolation of C. difficile from feces was achieved by selective enrichment culture. All isolates were characterized by standard molecular typing. Antimicrobial susceptibility testing was performed on selected isolates (n . = 29). Diarrheic piglets were more likely to shed C. difficile than the non-diseased (p = . 0.0124, χ2). In the cohort study, C. difficile was isolated from 40% samples on day 1, 50% on day 7, 20% on day 13, and 0% on days 20 and 42. All isolates were RT 237 and no antimicrobial resistance was detected. The decline of shedding of C. difficile to zero has public health implications because slaughter age pigs have a low likelihood of spreading C. difficile to consumers via pig meat

Details

Title: Persistence of Clostridium difficile RT 237 infection in a Western Australian piggery
Authors/Creators: P. Moono (Author/Creator) - The University of Western Australia
P. Putsathit (Author/Creator) - The University of Western Australia
D.R. Knight (Author/Creator) - The University of Western Australia
M.M. Squire (Author/Creator) - The University of Western Australia
D.J. Hampson (Author/Creator) - Murdoch University
N.F. Foster (Author/Creator) - School of Pathology and Laboratory Medicine
T.V. Riley (Author/Creator) - School of Pathology and Laboratory Medicine
Publication Details: Anaerobe, Vol.37, pp.62-66
Publisher: Academic Press
Identifiers: 991005544511507891
Copyright: © 2015 Elsevier Ltd.
Murdoch Affiliation: School of Veterinary and Life Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.120 Inflammatory Bowel Diseases & Infections; 1.120.1133 Clostridium Infections
Web Of Science research areas: Microbiology
ESI research areas: Microbiology