Journal article
Persistence of acquired immunity to Trichostrongylus colubriformis in sheep after termination of infection
International Journal for Parasitology, Vol.23(8), pp.1019-1026
1993
Abstract
Lambs were infected with 6000 Trichostrongylus colubriformis L3 per week for 18, 12 or 6 weeks, beginning at ages 14, 20 and 26 weeks, respectively. At the end of the primary infection subgroups had geometric mean adult worm burdens of 5000, 15,000 and 18,000, respectively. In the remaining sheep the worm population was removed with anthelmintic, and sheep had no further larval intake until challenged with T. colubriformis 1, 6, 12, 18 or 24 weeks later. In the groups given 18 or 12 weeks primary infection, establishment of challenge doses was low (less than 25% of establishment in helminth naive controls) in most animals at all challenge times. However, for the groups given 6 weeks primary infection, establishment was low only at the first two challenge times. Thereafter it had similar mean to control groups, but much greater variance. Other subgroups were challenged with T. colubriformis, Ostertagia circumcincta and Haemonchus contortus 1 week after worm removal. In these animals T. colubriformis establishment was not different to animals challenged at the same time with T. colubriformis alone, however immunity to T. colubriformis afforded little protection against the other species. The results of this experiment were incorporated into a simulation model of the population dynamics of T. colubriformis.
Details
- Title
- Persistence of acquired immunity to Trichostrongylus colubriformis in sheep after termination of infection
- Authors/Creators
- E.H. Barnes (Author/Creator)R.J. Dobson (Author/Creator)
- Publication Details
- International Journal for Parasitology, Vol.23(8), pp.1019-1026
- Publisher
- Elsevier BV
- Identifiers
- 991005541470307891
- Copyright
- © 2007 Elsevier B.V
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.163 Parasitology - General
- 1.163.1022 Anthelmintic Resistance
- Web Of Science research areas
- Parasitology
- ESI research areas
- Microbiology