Journal article
Pharmacogenetics of drug hypersensitivity
Pharmacogenomics, Vol.11(7), pp.973-987
2010
Abstract
Drug hypersensitivity reactions and severe cutaneous adverse drug reactions, such as Stevens-Johnson syndrome and toxic epidermal necrolysis, are examples of serious adverse drug reactions mediated through a combination of metabolic and immunological mechanisms that could traditionally not have been predicted based on the pharmacological characteristics of the drug alone. The discovery of new associations between these syndromes and specific HLA has created the promise that risk for these reactions could be predicted through pharmacogenetic screening, thereby avoiding serious morbidity and mortality associated with these types of drug reactions. Despite this, several hurdles exist in the translation of these associations into pharmacogenetic tests that could be routinely used in the clinical setting. HLA-B*5701 screening to prevent abacavir hypersensitivity syndrome is an example of a test now in widespread routine clinical use in the developed world.
Details
- Title
- Pharmacogenetics of drug hypersensitivity
- Authors/Creators
- E.J. Phillips (Author/Creator) - Royal Perth HospitalS. Mallal (Author/Creator) - Royal Perth Hospital
- Publication Details
- Pharmacogenomics, Vol.11(7), pp.973-987
- Publisher
- Ashley Publications Ltd.
- Identifiers
- 991005544489107891
- Copyright
- © 2010 Future Medicine Ltd
- Murdoch Affiliation
- Centre for Clinical Immunology and Biomedical Statistics; Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
279 File views/ downloads
83 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.265 Dermatology - Skin Allergies
- 1.265.1140 Drug Hypersensitivity
- Web Of Science research areas
- Pharmacology & Pharmacy
- ESI research areas
- Pharmacology & Toxicology