Journal article
Pharmacogenomics of HIV therapy: Summary of a workshop sponsored by the National Institute of Allergy and Infectious Diseases
HIV Clinical Trials, Vol.12(5), pp.277-285
2011
Abstract
Approximately 1 million people in the United States and over 30 million worldwide are living with human immunodeficiency virus type 1 (HIV-1). While mortality from untreated infection approaches 100%, survival improves markedly with use of contemporary antiretroviral therapies (ART). In the United States, 25 drugs are approved for treating HIV-1, and increasing numbers are available in resource-limited countries. Safe and effective ART is a cornerstone in the global least in part to human genetic variants that affect drug metabolism, drug disposition, and off-site drug targets. Defining effects of human genetic variants on HIV treatment toxicity, efficacy, and pharmacokinetics has far-reaching implications. In 2010, the National Institute of Allergy and Infectious Diseases sponsored a workshop entitled, Pharmacogenomics – A Path Towards Personalized HIV Care. This article summarizes workshop objectives, presentations, discussions, and recommendations derived from this meeting.
Details
- Title
- Pharmacogenomics of HIV therapy: Summary of a workshop sponsored by the National Institute of Allergy and Infectious Diseases
- Authors/Creators
- D.W. Haas (Author/Creator) - Vanderbilt UniversityD.R. Kuritzkes (Author/Creator) - Brigham and Women's HospitalM.D. Ritchie (Author/Creator) - Vanderbilt UniversityS. Amur (Author/Creator) - United States Food and Drug AdministrationB.F. Gage (Author/Creator) - Washington University in St. LouisG. Maartens (Author/Creator) - University of Cape TownD. Masys (Author/Creator) - Vanderbilt UniversityJ. Fellay (Author/Creator) - University of LausanneE. Phillips (Author/Creator) - Sir Charles Gairdner HospitalH.J. Ribaudo (Author/Creator) - Statistical Data Analysis Center Harvard School of Public Health, Boston, Massachusetts, USAK.A. Freedberg (Author/Creator) - Massachusetts General HospitalC. Petropoulos (Author/Creator) - Monogram BiosciencesT.A. Manolio (Author/Creator) - National Human Genome Research InstituteR.M. Gulick (Author/Creator) - Cornell UniversityR. Haubrich (Author/Creator) - University of California San DiegoP. Kim (Author/Creator) - National Institute of Allergy and Infectious DiseasesM. Dehlinger (Author/Creator) - National Institute of Allergy and Infectious DiseasesR. Abebe (Author/Creator) - Jackson FoundationA. Telenti (Author/Creator) - University of Lausanne
- Publication Details
- HIV Clinical Trials, Vol.12(5), pp.277-285
- Publisher
- Thomas Land Publishers Inc.
- Identifiers
- 991005541092507891
- Copyright
- © 2011 Thomas Land Publishers, Inc.
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
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- Citation topics
- 1 Clinical & Life Sciences
- 1.66 HIV
- 1.66.1372 HIV Comorbidities
- Web Of Science research areas
- Infectious Diseases
- Pharmacology & Pharmacy
- ESI research areas
- Clinical Medicine