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CC BY-NC-ND V4.0, Open Access
Journal article
Pharmacokinetics and Bioavailability of Single‐Dose Intramuscular and Intravenous Administration of Thiafentanil in Goats (Capra hircus)
Journal of veterinary pharmacology and therapeutics, Vol.48(4), pp.289-299
2025
PMID: 40116049
Appears in Open Access via Read & Publish Agreements
Abstract
Thiafentanil is a popular opioid agonist used for wildlife chemical immobilisation. Its effects are quickly and completely reversed by the antagonist naltrexone. Successful wildlife immobilisations using thiafentanil have been documented in a variety of wildlife species globally. The aim of this study was to describe the single‐dose intramuscular (IM) and intravenous (IV) pharmacokinetics of thiafentanil in goats at a dose of 90 μg/kg using a single cross‐over study. The IM dose was administered in the left Vastus lateralis. Plasma samples were collected up to 120 min after thiafentanil administration from two female and eight male adult goats. Samples were analysed by liquid chromatography–tandem mass spectrometry (LC–MS/MS). Pharmacokinetic parameters from one and two‐compartment models were estimated via a Bayesian approach. The two‐compartment model was preferred overall. The estimated bioavailability was 0.677 (90% Crl: 0.542–0.888), absorption rate constant ( k a ) was 0.058 1/min (90% Crl: 0.045–0.115) and clearance was 29.0 mL/min/kg (90% Crl: 23.7–36.3) from this model. This study provides key pharmacokinetic data on thiafentanil, supporting a two‐compartment model and offering insights into its absorption, bioavailability, and clearance when used for wildlife immobilisation.
Details
- Title
- Pharmacokinetics and Bioavailability of Single‐Dose Intramuscular and Intravenous Administration of Thiafentanil in Goats (Capra hircus)
- Authors/Creators
- Judith T. Christie - Murdoch UniversityMieghan Bruce - Murdoch University, Centre for Biosecurity and One HealthSilke Pfitzer - Tshwane University of TechnologyLiesel Laubscher - Wildlife Pharmaceuticals Rocky Drift White River South AfricaJacobus P. Raath - Wildlife Pharmaceuticals Rocky Drift White River South AfricaMichael Laurence - School of Veterinary Medicine, Harry Butler Institute Murdoch University Murdoch Western Australia AustraliaTracy Kellermann - Stellenbosch UniversityAndrew P. Woodward - University of Georgia
- Publication Details
- Journal of veterinary pharmacology and therapeutics, Vol.48(4), pp.289-299
- Publisher
- John Wiley & Sons Ltd.; HOBOKEN
- Number of pages
- 11
- Grant note
- South African Veterinary Association's Wildlife Group Research Fund Council of Australian University Librarians The authors would like to thank Dr. Chris Smith and the staff of for their assistance with the sample collection and goat husbandry. The use of the facilities at the Division of Clinical Pharmacology, Stellenbosch University is also acknowledged with appreciation. Open access publishing facilitated by Murdoch University, as part of the Wiley - Murdoch University agreement via the Council of Australian University Librarians.
- Identifiers
- 991005753926107891
- Copyright
- © 2025 The Author(s).
- Murdoch Affiliation
- Centre for Biosecurity and One Health; School of Veterinary Medicine
- Language
- English
- Resource Type
- Journal article
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- 1.43.1642 Veterinary Anesthesia
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