Journal article
Pharmacokinetics of moxidectin in the southern hairy-nosed wombat (Lasiorhinus latifrons)
Journal of Wildlife Diseases, Vol.47(3), pp.643-649
2011
Abstract
Sarcoptic mange, caused by Sarcoptes scabiei var. wombati, could be a significant threat to populations of southern hairy-nosed wombats (Lasiorhinus latifrons; SHNW) in Australia. Treatment is currently based on the off-label use of various parasiticidal drugs, with limited clinical efficacy trials. Our primary aim was to determine the pharmacokinetic parameters of a macrocyclic lactone, moxidectin, to assist in the development of effective treatment protocols. Pharmacokinetic parameters were determined in four female SHNW following a single subcutaneous injection of 0.2 mg/kg moxidectin. Blood samples were collected for 38 days following injection (August-September 2008), for analysis using liquid chromatography and tandem mass spectrometry. The mean peak plasma concentration occurred at 13.6 hr, with a mean peak plasma level of 98.6 ng/ml. The mean elimination half-life was 5.03 days, resulting in a mean area under the curve of 377 ng.day/ml. The peak plasma moxidectin concentration was higher than that seen in livestock species but the plasma elimination half-life was shorter. This study suggests that a single injection of 0.2 mg/kg moxidectin may not be sufficient to clear a mange infection in this species.
Details
- Title
- Pharmacokinetics of moxidectin in the southern hairy-nosed wombat (Lasiorhinus latifrons)
- Authors/Creators
- C.E. Death (Author/Creator)D.A. Taggart (Author/Creator)D.B. Williams (Author/Creator)R. Milne (Author/Creator)D.J. Schultz (Author/Creator)C.S. Holyoake (Author/Creator)K.S. Warren (Author/Creator)
- Publication Details
- Journal of Wildlife Diseases, Vol.47(3), pp.643-649
- Publisher
- Wildlife Disease Association
- Identifiers
- 991005541859707891
- Copyright
- © Wildlife Disease Association 2011
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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