Journal article
Pheromone discrimination by the Pheromone-Binding protein of Bombyx mori
Structure, Vol.14(10), pp.1577-1586
2006
Abstract
Pheromone-binding proteins are postulated to contribute to the exquisite specificity of the insect's olfactory system, acting as a filter by preferentially binding only one of the components of the natural pheromone. Here, we investigated the possible discrimination of the two very similar components of the natural pheromone gland from the silk moth, Bombyx mori, bombykol and bombykal, by the only pheromone-binding protein (BmorPBP) known to be expressed in the pheromone-detecting sensilla. Free-energy calculations and virtual docking indicate that both bombykol and bombykal bind to BmorPBP with similar affinity. In addition, in vitro competitive binding assays showed that both bombykol and bombykal were bound by BmorPBP with nearly the same high affinity. While BmorPBP might filter out other physiologically irrelevant compounds hitting the sensillar lymph, discrimination between the natural pheromone compounds must be achieved by molecular interactions with their cognate receptors.
Details
- Title
- Pheromone discrimination by the Pheromone-Binding protein of Bombyx mori
- Authors/Creators
- F. Gräter (Author/Creator) - Max Planck Institute for Biophysical ChemistryW. Xu (Author/Creator) - University of California, DavisW. Leal (Author/Creator) - University of California, DavisH. Grubmüller (Author/Creator) - Max Planck Institute for Biophysical Chemistry
- Publication Details
- Structure, Vol.14(10), pp.1577-1586
- Publisher
- Elsevier
- Identifiers
- 991005544305207891
- Copyright
- © 2006 Elsevier Ltd
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 3 Agriculture, Environment & Ecology
- 3.220 Smell & Taste Science
- 3.220.701 Olfactory Systems
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Biophysics
- Cell Biology
- ESI research areas
- Biology & Biochemistry