Photoligation of self-assembled DNA constructs containing anthracene-functionalized 2′-amino-LNA monomers

K. Pasternak; A. Pasternak; P. Gupta; R.N. Veedu; J. Wengel

doi:10.1016/j.bmc.2011.10.052

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Photoligation of self-assembled DNA constructs containing anthracene-functionalized 2′-amino-LNA monomers

Journal article

Peer reviewed

Photoligation of self-assembled DNA constructs containing anthracene-functionalized 2′-amino-LNA monomers

K. Pasternak, A. Pasternak, P. Gupta, R.N. Veedu and J. Wengel

Bioorganic & Medicinal Chemistry, Vol.19(24), pp.7407-7415

2011

DOI: https://doi.org/10.1016/j.bmc.2011.10.052

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Abstract

Efficient synthesis of a novel anthracene-functionalized 2′-amino-LNA phosphoramidite derivative is described together with its incorporation into oligodeoxynucleotides. Two DNA strands with the novel 2′-N-anthracenylmethyl-2′-amino-LNA monomers can be effectively cross-linked by photoligation at 366 nm in various types of DNA constructs. Successful application of three differently functionalized 2′-amino-LNA monomers in self-assembled higher ordered structures for simultaneous cross-linking and monitoring of assembly formation is furthermore demonstrated.

Details

Title: Photoligation of self-assembled DNA constructs containing anthracene-functionalized 2′-amino-LNA monomers
Authors/Creators: K. Pasternak (Author/Creator) - University of Southern Denmark
A. Pasternak (Author/Creator) - University of Southern Denmark
P. Gupta (Author/Creator) - University of Southern Denmark
R.N. Veedu (Author/Creator) - University of Southern Denmark
J. Wengel (Author/Creator) - University of Southern Denmark
Publication Details: Bioorganic & Medicinal Chemistry, Vol.19(24), pp.7407-7415
Publisher: Elsevier Ltd.
Identifiers: 991005542862607891
Copyright: © 2011 Elsevier Ltd.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 2 Chemistry; 2.170 Nucleic Acids Chemistry; 2.170.988 Oligonucleotide Modifications
Web Of Science research areas: Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry, Organic
ESI research areas: Chemistry