Phylogenetic Characterization and Seroprevalence of Senecavirus A from Swine Farms in Taiwan

Cheng-Ju Pan; Kuo-Jung Tsai; Jen-Chieh Chang; Ming-Chung Deng; Nien-Nung Lin; Kelly M Lager; Ian D Robertson; Yu-Liang Huang

doi:10.3390/ani15192786

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Phylogenetic Characterization and Seroprevalence of Senecavirus A from Swine Farms in Taiwan

Journal article

Open access

Peer reviewed

Phylogenetic Characterization and Seroprevalence of Senecavirus A from Swine Farms in Taiwan

Cheng-Ju Pan, Kuo-Jung Tsai, Jen-Chieh Chang, Ming-Chung Deng, Nien-Nung Lin, Kelly M Lager, Ian D Robertson and Yu-Liang Huang

Animals (Basel), Vol.15(19), 2786

2025

DOI: https://doi.org/10.3390/ani15192786

PMID: 41096382

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Abstract

seroprevalence

vesicular disease

phylogenetic analysis

Senecavirus A

Taiwan

A (SVA) is an emerging threat to swine populations due to its potential to cause vesicular lesions, which are difficult to differentiate from other vesicular diseases of swine such as foot and mouth disease (FMD), requiring significant resources for differential diagnosis. The first Taiwanese isolate of SVA was identified in 2006, although the first clinical case was not reported until 2012. The genetic characteristics and seroprevalence of SVA in Taiwan remain unclear. This study aimed to assess the seroprevalence and genetic diversity of SVA in nursery/weaned swine and finisher swine on Taiwanese pig farms. Phylogenetic analysis of seven Taiwanese SVA isolates revealed clustering into groups I and II. The 2006 and 2012 isolates shared 95.5% and 95.7% identity, respectively, with an early USA strain (MT360258), while more recent strains collected between 2018 and 2022 exhibited 95.7-98.8% identity with a 2020 USA strain (MZ733977). Serological analysis of swine from 300 farms showed significantly higher herd-level seroprevalence in nursery/weaned swine (53%) than finisher swine (6.7%). Furthermore, comparative analysis of nine known B cell epitopes showed high sequence conservation across Taiwanese and global strains. These findings provide important baseline data on the genetic diversity and seroprevalence of SVA in Taiwan and support the development of improved surveillance strategies for this emerging swine pathogen.

Details

Title: Phylogenetic Characterization and Seroprevalence of Senecavirus A from Swine Farms in Taiwan
Authors/Creators: Cheng-Ju Pan - Veterinary Research Institute, Ministry of Agriculture, New Taipei City 25158, Taiwan
Kuo-Jung Tsai - Veterinary Research Institute, Ministry of Agriculture, New Taipei City 25158, Taiwan
Jen-Chieh Chang - Veterinary Research Institute, Ministry of Agriculture, New Taipei City 25158, Taiwan
Ming-Chung Deng - Veterinary Research Institute, Ministry of Agriculture, New Taipei City 25158, Taiwan
Nien-Nung Lin - Plant (United States)
Kelly M Lager - National Animal Disease Center
Ian D Robertson - School of Veterinary Medicine, College of Environment and Life Sciences, Murdoch University, Perth, WA 6150, Australia
Yu-Liang Huang - Veterinary Research Institute, Ministry of Agriculture, New Taipei City 25158, Taiwan
Publication Details: Animals (Basel), Vol.15(19), 2786
Publisher: MDPI
Number of pages: 18
Identifiers: 991005821346307891
Murdoch Affiliation: College of Environmental and Life Sciences; School of Veterinary Medicine
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.104 Virology - General; 1.104.901 Enterovirus Research
Web Of Science research areas: Agriculture, Dairy & Animal Science; Veterinary Sciences; Zoology
ESI research areas: Plant & Animal Science