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Journal article
Phylogenetic Characterization and Seroprevalence of Senecavirus A from Swine Farms in Taiwan
Animals (Basel), Vol.15(19), 2786
2025
PMID: 41096382
Abstract
A (SVA) is an emerging threat to swine populations due to its potential to cause vesicular lesions, which are difficult to differentiate from other vesicular diseases of swine such as foot and mouth disease (FMD), requiring significant resources for differential diagnosis. The first Taiwanese isolate of SVA was identified in 2006, although the first clinical case was not reported until 2012. The genetic characteristics and seroprevalence of SVA in Taiwan remain unclear. This study aimed to assess the seroprevalence and genetic diversity of SVA in nursery/weaned swine and finisher swine on Taiwanese pig farms. Phylogenetic analysis of seven Taiwanese SVA isolates revealed clustering into groups I and II. The 2006 and 2012 isolates shared 95.5% and 95.7% identity, respectively, with an early USA strain (MT360258), while more recent strains collected between 2018 and 2022 exhibited 95.7-98.8% identity with a 2020 USA strain (MZ733977). Serological analysis of swine from 300 farms showed significantly higher herd-level seroprevalence in nursery/weaned swine (53%) than finisher swine (6.7%). Furthermore, comparative analysis of nine known B cell epitopes showed high sequence conservation across Taiwanese and global strains. These findings provide important baseline data on the genetic diversity and seroprevalence of SVA in Taiwan and support the development of improved surveillance strategies for this emerging swine pathogen.
Details
- Title
- Phylogenetic Characterization and Seroprevalence of Senecavirus A from Swine Farms in Taiwan
- Authors/Creators
- Cheng-Ju Pan - Veterinary Research Institute, Ministry of Agriculture, New Taipei City 25158, TaiwanKuo-Jung Tsai - Veterinary Research Institute, Ministry of Agriculture, New Taipei City 25158, TaiwanJen-Chieh Chang - Veterinary Research Institute, Ministry of Agriculture, New Taipei City 25158, TaiwanMing-Chung Deng - Veterinary Research Institute, Ministry of Agriculture, New Taipei City 25158, TaiwanNien-Nung Lin - PlantKelly M Lager - National Animal Disease CenterIan D Robertson - School of Veterinary Medicine, College of Environment and Life Sciences, Murdoch University, Perth, WA 6150, AustraliaYu-Liang Huang - Veterinary Research Institute, Ministry of Agriculture, New Taipei City 25158, Taiwan
- Publication Details
- Animals (Basel), Vol.15(19), 2786
- Publisher
- MDPI
- Number of pages
- 18
- Identifiers
- 991005821346307891
- Copyright
- © 2025 by the authors.
- Murdoch Affiliation
- College of Environmental and Life Sciences; School of Veterinary Medicine
- Language
- English
- Resource Type
- Journal article
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- 1 Clinical & Life Sciences
- 1.104 Virology - General
- 1.104.901 Enterovirus Research
- Web Of Science research areas
- Agriculture, Dairy & Animal Science
- Veterinary Sciences
- Zoology
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- Plant & Animal Science