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Journal article
Physical activity and brain amyloid beta: A longitudinal analysis of cognitively unimpaired older adults
Alzheimer's & dementia, Vol.20(2), pp.1350-1359
2023
Abstract
INTRODUCTION
The current study evaluated the relationship between habitual physical activity (PA) levels and brain amyloid beta (Aβ) over 15 years in a cohort of cognitively unimpaired older adults.
METHODS
PA and Aβ measures were collected over multiple timepoints from 731 cognitively unimpaired older adults participating in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Aging. Regression modeling examined cross-sectional and longitudinal relationships between PA and brain Aβ. Moderation analyses examined apolipoprotein E (APOE) ε4 carriage impact on the PA-Aβ relationship.
RESULTS
PA was not associated with brain Aβ at baseline (β = –0.001, p = 0.72) or over time (β = –0.26, p = 0.24). APOE ε4 status did not moderate the PA-Aβ relationship over time (β = 0.12, p = 0.73). Brain Aβ levels did not predict PA trajectory (β = –54.26, p = 0.59).
DISCUSSION
Our study did not identify a relationship between habitual PA and brain Aβ levels.
Details
- Title
- Physical activity and brain amyloid beta: A longitudinal analysis of cognitively unimpaired older adults
- Authors/Creators
- Michael G SleeStephanie R Rainey-Smith - Murdoch University, Centre for Healthy AgeingVictor L Villemagne - University of PittsburghJames D Doecke - Australian e-Health Research CentreHamid R Sohrabi - Murdoch University, Centre for Healthy AgeingKevin Taddei - Australian Alzheimer’s Research FoundationDavid Ames - The University of MelbourneVincent Dore - CSIRO Health and BiosecurityPaul Maruff - Florey Institute of Neuroscience and Mental HealthSimon M Laws - Edith Cowan UniversityColin L Masters - Florey Institute of Neuroscience and Mental HealthChristopher C Rowe - Florey Institute of Neuroscience and Mental HealthRalph N MartinsKirk I Erickson - University of PittsburghBelinda M Brown - Murdoch University, Centre for Healthy Ageing
- Publication Details
- Alzheimer's & dementia, Vol.20(2), pp.1350-1359
- Publisher
- Wiley Periodicals LLC on behalf of Alzheimer's Association.
- Identifiers
- 991005617461907891
- Copyright
- © 2023 The Authors.
- Murdoch Affiliation
- Centre for Healthy Ageing
- Language
- English
- Resource Type
- Journal article
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